{"id":"W2111152776","doi":"10.1097/cji.0b013e3181b290f1","title":"Therapeutic (High) Doses of Rituximab Activate Calcium Mobilization and Inhibit B-cell Growth via an Unusual Mechanism Triggered Independently of Both CD20 and Fcγ Receptors","year":2009,"lang":"en","type":"article","venue":"Journal of Immunotherapy","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Monoclonal antibody; CD20; Chemistry; Calcium in biology; Rituximab; Intracellular; Cytotoxic T cell; Cell biology; Receptor; Monoclonal; Antibody; Cancer research; Pharmacology; Immunology; Biology; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000557057,0.0001974019,0.0006535036,0.0003499272,0.00006691478,0.00002196707,0.0001296835,0.0001390447,0.00008117305],"category_scores_gemma":[0.00001988022,0.0001404443,0.0001249592,0.0002216032,0.0001385536,0.0002621675,0.00001859032,0.0003302266,5.481676e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003915387,"about_ca_system_score_gemma":0.0001271786,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001759821,"about_ca_topic_score_gemma":0.000003037773,"domain_scores_codex":[0.9981895,0.0001662653,0.0006871006,0.0001640033,0.0005789285,0.000214204],"domain_scores_gemma":[0.9987121,0.0001077265,0.0005448505,0.0001442216,0.0003506352,0.0001404722],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006018095,0.00109079,0.002339041,0.0001121837,0.000199948,0.00001570301,0.001079182,0.00000183655,0.9348621,0.0004624795,0.00001915361,0.05379944],"study_design_scores_gemma":[0.0116205,0.00917119,0.03769945,0.0002870125,0.00008962992,0.0003159089,0.0004043322,0.0001276262,0.9345127,0.005304056,0.0002769459,0.000190626],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993144,0.004779106,0.001160227,0.000481849,0.00009574251,0.0002421542,0.000008252875,0.000006670944,0.00008194981],"genre_scores_gemma":[0.9907157,0.007848076,0.0008397753,0.0002574389,0.0001008979,0.00000113229,0.000005807678,0.00002303149,0.0002080738],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05360882,"threshold_uncertainty_score":0.5727155,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01781289045647958,"score_gpt":0.2976385071035246,"score_spread":0.279825616647045,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}