{"id":"W2111152776","doi":"10.1097/cji.0b013e3181b290f1","title":"Therapeutic (High) Doses of Rituximab Activate Calcium Mobilization and Inhibit B-cell Growth via an Unusual Mechanism Triggered Independently of Both CD20 and Fcγ Receptors","year":2009,"lang":"en","type":"article","venue":"Journal of Immunotherapy","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Monoclonal antibody; CD20; Chemistry; Calcium in biology; Rituximab; Intracellular; Cytotoxic T cell; Cell biology; Receptor; Monoclonal; Antibody; Cancer research; Pharmacology; Immunology; Biology; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001499174,0.00028068,0.0003290815,0.0001766939,0.0001159486,0.0003137741,0.0002583902,0.0004424255,0.0009245053],"category_scores_gemma":[0.0002085058,0.000109917,0.0001653036,0.0001128826,0.0002496064,0.000184078,0.0002113271,0.0006253679,0.0002449586],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002705573,"about_ca_system_score_gemma":0.0001320397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001339631,"about_ca_topic_score_gemma":0.0002718235,"domain_scores_codex":[0.9998434,0.00003567594,0.000007580397,0.00001930676,0.00004504068,0.00004899294],"domain_scores_gemma":[0.999926,0.00002416124,0.00001639239,0.0000121063,0.000005888256,0.00001541571],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000143464,0.00005121596,0.00009711197,0.00003542676,0.000006501309,0.00009900383,0.00001344907,0.0001126642,0.9964303,0.0002113921,0.00007786464,0.002721528],"study_design_scores_gemma":[0.0001089044,0.001100308,0.002020941,0.00000682234,0.00003722757,0.0008020411,0.00001638444,0.001053794,0.9920416,0.0001909633,0.002616418,0.00000441925],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9861843,0.005054635,0.005864756,0.000257401,0.0000440242,0.00005281639,0.00008718562,0.00014388,0.002311084],"genre_scores_gemma":[0.9966324,0.0008325133,0.001807662,0.00009249093,0.00003722679,0.00002847225,0.00007690089,0.00001140954,0.0004810456],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009245053,"threshold_uncertainty_score":0.003092766,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01781289045647958,"score_gpt":0.2976385071035246,"score_spread":0.279825616647045,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}