{"id":"W2111154371","doi":"10.1186/1471-2350-12-137","title":"Pharmacogenetic analysis of the effects of polymorphisms in APOE, IDE and IL1B on a ketone body based therapeutic on cognition in mild to moderate Alzheimer's disease; a randomized, double-blind, placebo-controlled study","year":2011,"lang":"en","type":"article","venue":"BMC Medical Genetics","topic":"Diet and metabolism studies","field":"Medicine","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"Douglas College","funders":"","keywords":"Apolipoprotein E; Placebo; Pharmacogenetics; Genotype; Polymorphism (computer science); Alzheimer's disease; Medicine; Internal medicine; Randomized controlled trial; Allele; Dementia; Disease; Oncology; Psychology; Genetics; Biology; Gene; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001919529,0.001352415,0.002727822,0.0005827122,0.0005378057,0.0006736437,0.000843258,0.001653286,0.003541514],"category_scores_gemma":[0.002498832,0.0006210506,0.00163155,0.0005406157,0.001107029,0.0005020131,0.0003351082,0.001451632,0.000350329],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005188838,"about_ca_system_score_gemma":0.0007086972,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007177654,"about_ca_topic_score_gemma":0.001137574,"domain_scores_codex":[0.9987454,0.0007254045,0.0001175472,0.0001938681,0.0001119191,0.0001058212],"domain_scores_gemma":[0.9984193,0.000600016,0.0003964411,0.0001456164,0.0001148259,0.0003237761],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9825423,0.008300381,0.0009278763,0.0002569371,0.0009917613,0.00002076754,0.00002470203,0.00007940707,0.002509104,0.00002320001,0.00007707289,0.004246525],"study_design_scores_gemma":[0.8432656,0.1457888,0.00772933,0.00002352896,0.001731671,0.00002717971,0.0000151071,0.0003050959,0.0008046288,0.0001054323,0.0001884042,0.00001534799],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996191,0.001433568,0.0003517011,0.000141047,0.0001457586,0.001111353,0.0002543295,0.00002467326,0.0003466549],"genre_scores_gemma":[0.9952227,0.0007798614,0.0009075914,0.0002565928,0.0002559342,0.001684553,0.0002319565,0.000008125787,0.0006526275],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003541514,"threshold_uncertainty_score":0.0118475,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05666403679908684,"score_gpt":0.3295646466119551,"score_spread":0.2729006098128682,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}