{"id":"W2111155915","doi":"10.1124/dmd.32.1.20","title":"SUPPRESSION OF DRUG-METABOLIZING ENZYMES AND EFFLUX TRANSPORTERS IN THE INTESTINE OF ENDOTOXIN-TREATED RATS","year":2004,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":119,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Multidrug resistance-associated protein 2; P-glycoprotein; Efflux; CYP3A; Jejunum; Drug metabolism; Pharmacology; Metabolism; Lactate dehydrogenase; Small intestine; Biology; Chemistry; Cytochrome P450; Endocrinology; Transporter; Internal medicine; Biochemistry; ATP-binding cassette transporter; Enzyme; Multiple drug resistance; Antibiotics; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002968523,0.0007201243,0.001097624,0.0005288493,0.0003279743,0.0003999841,0.0002887746,0.0006448802,0.002177266],"category_scores_gemma":[0.0005777734,0.0004822246,0.000438557,0.0002645749,0.001056873,0.0007528666,0.0002998309,0.00178184,0.0003428568],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004278547,"about_ca_system_score_gemma":0.0006168922,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008208632,"about_ca_topic_score_gemma":0.0009318894,"domain_scores_codex":[0.9997185,0.00005124883,0.00002341545,0.00005266518,0.00005479969,0.00009943423],"domain_scores_gemma":[0.9992869,0.0001165266,0.0001873343,0.00008713765,0.00006269129,0.0002594084],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01442109,0.000598355,0.0006843067,0.00005283146,0.00001950851,0.0001810519,0.00006506194,0.0001714916,0.9800621,0.0002198676,0.00006524269,0.003459144],"study_design_scores_gemma":[0.000855441,0.01342568,0.01270014,0.00001869144,0.0001117445,0.0003829236,0.0002765275,0.002378615,0.9680148,0.000381624,0.001417283,0.00003652944],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982302,0.0003519427,0.0008230227,0.0001767424,0.00004718102,0.00001298361,0.0001101501,0.00004702394,0.0002008314],"genre_scores_gemma":[0.9946967,0.0005932593,0.001582648,0.0001362333,0.0000425634,0.00006553772,0.0003164653,0.00003970487,0.002526789],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002177266,"threshold_uncertainty_score":0.007283688,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00617496178791615,"score_gpt":0.2261655938081449,"score_spread":0.2199906320202287,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}