{"id":"W2111165209","doi":"10.1039/c2ob25103e","title":"Conformational, steric and electronic effects on the site- and chemoselectivity of the metal-catalyzed reaction of N-bis(trimethylsilyl)methyl, N-(2-indolyl)methyl α-diazoamides","year":2012,"lang":"en","type":"article","venue":"Organic & Biomolecular Chemistry","topic":"Cyclopropane Reaction Mechanisms","field":"Chemistry","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Regina","funders":"Natural Sciences and Engineering Research Council of Canada; Royal Society of Chemistry; Royal Society; University of Regina","keywords":"Chemoselectivity; Chemistry; Steric effects; Trimethylsilyl; Substituent; Indole test; Moiety; Amide; Medicinal chemistry; Diazo; Stereochemistry; Catalysis; Electronic effect; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002014648,0.0002753665,0.0001796936,0.00007938634,0.00009724969,0.0001716714,0.0002839857,0.0001924685,0.001424015],"category_scores_gemma":[0.0002975718,0.0001430379,0.0001334105,0.00006531872,0.0001956693,0.0001804971,0.0001598052,0.0002129178,0.0004179817],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002555743,"about_ca_system_score_gemma":0.0001771411,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004497737,"about_ca_topic_score_gemma":0.001148701,"domain_scores_codex":[0.9998734,0.00002770807,0.000009148103,0.00002837251,0.00003012787,0.00003117716],"domain_scores_gemma":[0.9998541,0.00005070624,0.0000429869,0.00001367508,0.00001732518,0.00002117255],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001289018,0.000008057086,0.0001176311,0.00003272719,0.000004287526,0.00004320447,0.00002056178,0.0001443329,0.9982483,0.0001057183,0.00001899727,0.001127308],"study_design_scores_gemma":[0.000005756564,0.00008774102,0.0005457565,0.00000176625,0.00000390638,0.00005210773,0.000007881779,0.0004249578,0.998514,0.00001360848,0.0003390946,0.000003403146],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954752,0.0004250239,0.0009854503,0.00002813619,0.000008441749,0.000009833516,0.0000495836,0.00003382853,0.002984441],"genre_scores_gemma":[0.9981887,0.0002211395,0.0006054599,0.00001505317,0.000003045068,0.000008000879,0.00005603801,0.000008470727,0.0008941715],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001424015,"threshold_uncertainty_score":0.004763782,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005606866939869628,"score_gpt":0.2039210268136958,"score_spread":0.1983141598738262,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}