{"id":"W2111181123","doi":"10.3324/haematol.13359","title":"Enhanced alternative splicing of the FLVCR1 gene in Diamond Blackfan anemia disrupts FLVCR1 expression and function that are critical for erythropoiesis","year":2008,"lang":"en","type":"article","venue":"Haematologica","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre; University Health Network; University of Toronto; Hospital for Sick Children","funders":"","keywords":"Diamond–Blackfan anemia; Erythropoiesis; Biology; Ineffective erythropoiesis; Alternative splicing; Haematopoiesis; Cell biology; Myeloid; Myelopoiesis; Anemia; Cancer research; Stem cell; Genetics; Gene; RNA; Gene isoform; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001972343,0.0004585008,0.0002141304,0.0002939011,0.0001422914,0.0002076048,0.0003463809,0.0005275601,0.001444932],"category_scores_gemma":[0.0001293831,0.0001528472,0.0002578358,0.0001254688,0.0003395084,0.00009052056,0.0002334116,0.0004770322,0.0004111411],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003478411,"about_ca_system_score_gemma":0.0001976897,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005405144,"about_ca_topic_score_gemma":0.0008548855,"domain_scores_codex":[0.9998154,0.00003306613,0.00002452137,0.00004813223,0.00005363376,0.0000252264],"domain_scores_gemma":[0.9998482,0.00004152355,0.00005684491,0.00001848574,0.000007167004,0.00002768965],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003807573,0.00002049961,0.0002202998,0.00001838043,0.000004243231,0.0001675168,0.00001165036,0.0001144483,0.9985729,0.0001118758,0.00002574118,0.0006942341],"study_design_scores_gemma":[0.0000490212,0.0002833659,0.00587001,0.00001044802,0.00002990759,0.002408646,0.00002683083,0.002056158,0.9860319,0.00006699872,0.003156138,0.00001065323],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945919,0.0005294657,0.003690994,0.00007589118,0.00002562169,0.00005162394,0.0003671319,0.00009537523,0.0005719712],"genre_scores_gemma":[0.9939179,0.0002592783,0.00399768,0.00005279694,0.000009438027,0.00005066756,0.0005234527,0.00003066577,0.001158055],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001444932,"threshold_uncertainty_score":0.004833817,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02931776947713871,"score_gpt":0.2814989816257482,"score_spread":0.2521812121486095,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}