{"id":"W2111193397","doi":"10.1021/bi034013b","title":"NF-κB Induction by Bisperoxovanadium Compounds Requires CD45, p36<sup>LAT</sup>, PKC, and IKK Activity and Exhibits Kinetics of Activation Comparable to Those of TCR/CD28 Coengagement","year":2003,"lang":"en","type":"article","venue":"Biochemistry","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Canadian Institutes of Health Research","keywords":"Jurkat cells; Kinase; Molecular biology; Protein kinase C; Gene isoform; Cell biology; Signal transduction; IκB kinase; Chemistry; Biology; NF-κB; T cell; Biochemistry; Gene; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007595812,0.0003455972,0.0001938988,0.0001197264,0.00009539307,0.0002222595,0.0001613412,0.0001324009,0.001339548],"category_scores_gemma":[0.0001005903,0.0001259004,0.0001808902,0.0001280735,0.0001485393,0.0001589133,0.0001428171,0.0003289604,0.0004006269],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002854385,"about_ca_system_score_gemma":0.0001538816,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005052791,"about_ca_topic_score_gemma":0.0009695233,"domain_scores_codex":[0.9998999,0.000008438275,0.000008824449,0.00001967823,0.00003623497,0.00002700279],"domain_scores_gemma":[0.9999288,0.000009155079,0.00002365184,0.00001059407,0.000009104501,0.00001872681],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009080934,0.00001011472,0.00006077007,0.00002263037,0.000001997359,0.00001427549,0.000004495901,0.00002349639,0.9991927,0.00003172529,0.000008766657,0.0005382306],"study_design_scores_gemma":[0.000007560227,0.0001054797,0.0007841897,0.000001858681,0.000003514692,0.00008754846,0.000006746848,0.0001433501,0.9979469,0.00002317512,0.0008883595,0.000001191431],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931309,0.001361964,0.003358007,0.00003833679,0.00002501057,0.00003786324,0.0002609399,0.00007665496,0.001710355],"genre_scores_gemma":[0.9930819,0.000778128,0.002307318,0.00002134228,0.000007944702,0.00004641244,0.000510834,0.0000206908,0.003225473],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001339548,"threshold_uncertainty_score":0.004481256,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02116751544831606,"score_gpt":0.2562389569760837,"score_spread":0.2350714415277676,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}