{"id":"W2111193397","doi":"10.1021/bi034013b","title":"NF-κB Induction by Bisperoxovanadium Compounds Requires CD45, p36<sup>LAT</sup>, PKC, and IKK Activity and Exhibits Kinetics of Activation Comparable to Those of TCR/CD28 Coengagement","year":2003,"lang":"en","type":"article","venue":"Biochemistry","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Canadian Institutes of Health Research","keywords":"Jurkat cells; Kinase; Molecular biology; Protein kinase C; Gene isoform; Cell biology; Signal transduction; IκB kinase; Chemistry; Biology; NF-κB; T cell; Biochemistry; Gene; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002667297,0.0002495133,0.000290448,0.00005314064,0.00007817964,0.00002403799,0.0001287108,0.0002534732,0.00001269389],"category_scores_gemma":[0.0002059478,0.000271854,0.00005002423,0.0001545251,0.0001892869,0.00001175649,0.0001106795,0.0001422021,7.946127e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000408303,"about_ca_system_score_gemma":0.00006469362,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005293226,"about_ca_topic_score_gemma":0.000005817089,"domain_scores_codex":[0.9986241,0.00008675109,0.0003205059,0.0004956215,0.0002162694,0.0002567402],"domain_scores_gemma":[0.9990188,0.00003744743,0.000217791,0.0004163067,0.0001566298,0.0001529527],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001141203,0.0001943801,0.001071712,0.0001638254,0.00005970056,5.787073e-7,0.0001108396,0.0001546945,0.9934177,0.00002136196,0.004354543,0.0003365062],"study_design_scores_gemma":[0.0006713999,0.0002545203,0.0004723448,0.00008945336,0.00003234061,0.00001271928,0.0002236654,0.00007716282,0.9944245,0.00002074684,0.003464277,0.0002568224],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972141,0.0006058147,0.00103895,0.0001040516,0.00004331555,0.0002351047,0.0000929098,0.00001322053,0.0006524688],"genre_scores_gemma":[0.9980952,0.00009403834,0.001092504,0.00005787288,0.00006588608,0.00001496721,0.0001389412,0.00002734067,0.0004132933],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001006809,"threshold_uncertainty_score":0.9999734,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02116751544831606,"score_gpt":0.2562389569760837,"score_spread":0.2350714415277676,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}