{"id":"W2111211062","doi":"10.2337/db12-0315","title":"Human β-Cell Killing by Autoreactive Preproinsulin-Specific CD8 T Cells Is Predominantly Granule-Mediated With the Potency Dependent Upon T-Cell Receptor Avidity","year":2012,"lang":"en","type":"article","venue":"Diabetes","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Medical Research Council; Wellcome Trust","keywords":"Cytotoxic T cell; Biology; Degranulation; CD8; T cell; Epitope; Cell biology; Immunology; Antigen; Immune system; Receptor; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004100094,0.0003719485,0.0002783285,0.00003634579,0.0003088403,0.00007801333,0.0003831235,0.0002607562,0.00008725622],"category_scores_gemma":[0.00001607987,0.00026952,0.0001529521,0.0001337197,0.0001155591,0.0000244342,0.0001169326,0.0002570349,0.0001023444],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000410553,"about_ca_system_score_gemma":0.00004238511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004262354,"about_ca_topic_score_gemma":0.000006951025,"domain_scores_codex":[0.9978733,0.0001466482,0.0002738294,0.0005718286,0.0002990698,0.0008353115],"domain_scores_gemma":[0.9988253,0.00005287913,0.0002871923,0.0005295341,0.0001141084,0.0001909491],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000241845,0.0006034435,0.01059192,0.00002578375,0.00007860569,2.832082e-7,0.0003420303,0.0000107781,0.954844,0.000003258896,0.03296182,0.0005139139],"study_design_scores_gemma":[0.001036912,0.0002964508,0.0008136699,0.00001809537,0.00005891086,1.299406e-7,0.0004666714,0.00002332171,0.9334293,0.0000112339,0.06342647,0.0004188195],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919291,0.004448435,0.00004860859,0.0001801137,0.0002384028,0.0005137857,0.000333215,0.00004120793,0.002267136],"genre_scores_gemma":[0.9964042,0.0003763311,0.0001103518,0.0003240377,0.0002214375,0.00009033374,0.000643626,0.00006997962,0.00175971],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03046465,"threshold_uncertainty_score":0.9999757,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004961175375928327,"score_gpt":0.1952416608675154,"score_spread":0.1902804854915871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}