{"id":"W2111211062","doi":"10.2337/db12-0315","title":"Human β-Cell Killing by Autoreactive Preproinsulin-Specific CD8 T Cells Is Predominantly Granule-Mediated With the Potency Dependent Upon T-Cell Receptor Avidity","year":2012,"lang":"en","type":"article","venue":"Diabetes","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Medical Research Council; Wellcome Trust","keywords":"Cytotoxic T cell; Biology; Degranulation; CD8; T cell; Epitope; Cell biology; Immunology; Antigen; Immune system; Receptor; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000168514,0.0003454862,0.0002449768,0.0001099955,0.00006493107,0.0003477925,0.0001331974,0.0002157578,0.001241989],"category_scores_gemma":[0.0001519995,0.00009647023,0.0001692538,0.0001054372,0.0001375339,0.0002009687,0.000179768,0.0004702595,0.0004776177],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009805395,"about_ca_system_score_gemma":0.00007412351,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007701292,"about_ca_topic_score_gemma":0.00006559167,"domain_scores_codex":[0.9998302,0.00003781862,0.00001979062,0.00004566271,0.00003620561,0.00003028108],"domain_scores_gemma":[0.99989,0.00003219191,0.00002526199,0.00002518465,0.00001227881,0.00001504586],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001145606,0.0000321377,0.0003536718,0.00003288238,0.000005510006,0.0000252366,0.00001736417,0.00004161434,0.9968779,0.00004493014,0.00001316085,0.002441096],"study_design_scores_gemma":[0.00004452148,0.0009826798,0.004127108,0.000008760087,0.00002368063,0.0006430782,0.00002121139,0.0005440693,0.9915851,0.00005696317,0.001958557,0.000004212221],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944941,0.001622967,0.00249329,0.00002248516,0.00001350203,0.00003173208,0.00007804823,0.00004682021,0.001197037],"genre_scores_gemma":[0.9968973,0.0007075922,0.001332257,0.00002285595,0.00001339008,0.00002842034,0.0002016761,0.00001004604,0.0007863238],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001241989,"threshold_uncertainty_score":0.004154861,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004961175375928327,"score_gpt":0.1952416608675154,"score_spread":0.1902804854915871,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}