{"id":"W2111213257","doi":"10.1128/mcb.21.14.4725-4736.2001","title":"Myc Potentiates Apoptosis by Stimulating Bax Activity at the Mitochondria","year":2001,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":144,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; McMaster University; University of Toronto; Ontario Institute for Cancer Research","funders":"Canadian Institutes of Health Research; University of Pennsylvania","keywords":"Biology; Apoptosis; Cytochrome c; Mitochondrion; Cell biology; Bcl-2-associated X protein; DNA fragmentation; Programmed cell death; Bcl-2 family; Mitochondrial apoptosis-induced channel; Molecular biology; Signal transduction; Endoplasmic reticulum; Poly ADP ribose polymerase; Caspase 3; DNA; Biochemistry; Polymerase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001536602,0.0002119603,0.0001640188,0.0000266864,0.0002799419,0.0000294278,0.0001395215,0.0002679014,0.000070863],"category_scores_gemma":[0.00002479498,0.0001554982,0.0001228783,0.00008105522,0.0001373569,0.000003475485,0.0002222173,0.00009617856,0.00001059073],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001273524,"about_ca_system_score_gemma":0.00001396998,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007358573,"about_ca_topic_score_gemma":0.00001843885,"domain_scores_codex":[0.9987902,0.0001521699,0.0001628659,0.0004877625,0.00008517299,0.0003218322],"domain_scores_gemma":[0.9994125,0.00001498383,0.00008410766,0.0003656092,0.00003996991,0.00008284498],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005897722,0.00003258564,0.0007200086,0.000004749453,0.00005893443,0.000003346083,0.00001432634,0.00005545139,0.9898533,0.0001755904,0.0004834665,0.008539232],"study_design_scores_gemma":[0.0004448792,0.0002242098,0.0001632884,0.000003976143,0.00004418077,0.00002843297,0.00002202289,0.000696399,0.9655047,0.0003008276,0.03234369,0.0002234206],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9458817,0.003743188,0.04909309,0.0003693209,0.0001959229,0.000217438,0.00001583615,0.00001550563,0.0004680197],"genre_scores_gemma":[0.996033,0.0004300645,0.0002502078,0.0002662874,0.000108085,0.00002082987,0.0003998863,0.00002666032,0.002465006],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05015129,"threshold_uncertainty_score":0.6341032,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005090655932053229,"score_gpt":0.21726991160589,"score_spread":0.2121792556738367,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}