{"id":"W2111213257","doi":"10.1128/mcb.21.14.4725-4736.2001","title":"Myc Potentiates Apoptosis by Stimulating Bax Activity at the Mitochondria","year":2001,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":144,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; McMaster University; University of Toronto; Ontario Institute for Cancer Research","funders":"Canadian Institutes of Health Research; University of Pennsylvania","keywords":"Biology; Apoptosis; Cytochrome c; Mitochondrion; Cell biology; Bcl-2-associated X protein; DNA fragmentation; Programmed cell death; Bcl-2 family; Mitochondrial apoptosis-induced channel; Molecular biology; Signal transduction; Endoplasmic reticulum; Poly ADP ribose polymerase; Caspase 3; DNA; Biochemistry; Polymerase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000115832,0.0002912959,0.0001545752,0.0002025371,0.0001178364,0.0002733414,0.000119961,0.0001666312,0.001212703],"category_scores_gemma":[0.0001421742,0.00009121019,0.000190934,0.0001035142,0.0001645682,0.0001763519,0.0002425159,0.0005224989,0.0002996175],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002031018,"about_ca_system_score_gemma":0.0001145896,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001701408,"about_ca_topic_score_gemma":0.0002760986,"domain_scores_codex":[0.9998454,0.00003665667,0.00001536046,0.00001994491,0.00004283511,0.00003981181],"domain_scores_gemma":[0.9998534,0.00003562996,0.00003597752,0.00002240396,0.00001698489,0.00003553735],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001929342,0.00003407616,0.0002313077,0.00002904438,0.000003720479,0.0000504974,0.000009158223,0.00006243529,0.9982072,0.0001219664,0.00002704963,0.001030689],"study_design_scores_gemma":[0.00002761991,0.0005888616,0.004037992,0.000007835208,0.00001531164,0.0005067422,0.00002602579,0.0007666015,0.9916424,0.00008070848,0.002296627,0.000003151772],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996451,0.000994085,0.0009945644,0.00007227665,0.00001940316,0.000008092111,0.00008017618,0.00004084683,0.001339541],"genre_scores_gemma":[0.9980389,0.0004982151,0.000394117,0.00001621775,0.000008757177,0.00000827114,0.0001103111,0.000005276091,0.0009197757],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001212703,"threshold_uncertainty_score":0.004056931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005090655932053229,"score_gpt":0.21726991160589,"score_spread":0.2121792556738367,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}