{"id":"W2111228244","doi":"10.1111/j.1365-2958.2012.08179.x","title":"Double locking of an <i>Escherichia coli</i> promoter by two repressors prevents premature colicin expression and cell lysis","year":2012,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Circulatory and Respiratory Health; Biotechnology and Biological Sciences Research Council","keywords":"Repressor lexA; Colicin; Repressor; Biology; SOS response; Operon; DNA damage; Transcription (linguistics); Transcription factor; Escherichia coli; Promoter; DNA repair; Gene; DNA; Genetics; Cell biology; Molecular biology; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001548524,0.0003264264,0.0003741744,0.0001691139,0.00008716878,0.0005225076,0.0004083305,0.0002325693,0.0009357811],"category_scores_gemma":[0.0002976283,0.0001751864,0.0002213393,0.00008604651,0.0003677308,0.0002131309,0.0003981816,0.0005007486,0.0004878143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003773394,"about_ca_system_score_gemma":0.0003356543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002983419,"about_ca_topic_score_gemma":0.0003833243,"domain_scores_codex":[0.9996774,0.00003791283,0.00002537424,0.00008671921,0.00007209049,0.0001004909],"domain_scores_gemma":[0.9995955,0.00005571688,0.0001526041,0.00006307376,0.00002928769,0.0001038151],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007695999,0.00002078831,0.0001217547,0.00001199171,0.000001586263,0.00001027501,0.00000424481,0.00002543439,0.9989653,0.00006887132,0.00001445008,0.0006785051],"study_design_scores_gemma":[0.000005068587,0.00007871489,0.0005723794,0.000002464566,0.000003693294,0.00006926963,0.000004753503,0.0003057713,0.9983014,0.00001223303,0.0006415657,0.00000259817],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904287,0.0006838253,0.007383968,0.00007419396,0.00002629821,0.00001749815,0.00007931782,0.0003236156,0.0009825105],"genre_scores_gemma":[0.995789,0.0001471013,0.002168166,0.00004045227,0.00000893663,0.00001596284,0.0001673227,0.00007416281,0.00158902],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009357811,"threshold_uncertainty_score":0.003130555,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004289222280487486,"score_gpt":0.2199754712111081,"score_spread":0.2156862489306207,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}