{"id":"W2111228244","doi":"10.1111/j.1365-2958.2012.08179.x","title":"Double locking of an <i>Escherichia coli</i> promoter by two repressors prevents premature colicin expression and cell lysis","year":2012,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Circulatory and Respiratory Health; Biotechnology and Biological Sciences Research Council","keywords":"Repressor lexA; Colicin; Repressor; Biology; SOS response; Operon; DNA damage; Transcription (linguistics); Transcription factor; Escherichia coli; Promoter; DNA repair; Gene; DNA; Genetics; Cell biology; Molecular biology; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001951374,0.0002509828,0.0003075937,0.00004945366,0.00005787959,0.00001400053,0.0002656472,0.000594575,0.00001633494],"category_scores_gemma":[0.00001025353,0.0002277848,0.00007696475,0.00009265626,0.0001711458,0.000007336658,0.0003327905,0.0001562909,0.000002132033],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008461392,"about_ca_system_score_gemma":0.0000216384,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003091598,"about_ca_topic_score_gemma":0.000005664141,"domain_scores_codex":[0.9985563,0.0001710476,0.0003006009,0.000485302,0.00004675311,0.0004400278],"domain_scores_gemma":[0.9990847,0.000004539069,0.0002048783,0.0005378225,0.00005497832,0.0001130716],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001710422,0.0002343333,0.0008240202,0.00004019435,0.00004597285,0.000001453769,0.00007972358,0.000007593618,0.9979441,0.000007361353,0.0004800505,0.0001641492],"study_design_scores_gemma":[0.001260832,0.0003665761,0.0001155223,0.00001753502,0.00004687762,0.00003361407,0.00002210709,0.000003660166,0.9780444,0.00000924895,0.01983084,0.000248775],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960661,0.002818021,0.0003194909,0.00005055232,0.0001373562,0.0003890706,0.00007135599,0.00001625214,0.0001318178],"genre_scores_gemma":[0.9963616,0.0001106689,0.002528001,0.0002633773,0.0000718814,0.0000268208,0.0004200966,0.00003803655,0.0001795597],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01989969,"threshold_uncertainty_score":0.9288793,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004289222280487486,"score_gpt":0.2199754712111081,"score_spread":0.2156862489306207,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}