{"id":"W2111243299","doi":"10.1016/j.jmb.2013.02.025","title":"Glycan Shifting on Hepatitis C Virus (HCV) E2 Glycoprotein Is a Mechanism for Escape from Broadly Neutralizing Antibodies","year":2013,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Hepatitis C virus research","field":"Medicine","cited_by":113,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Research Resources; National Research Council Canada; National Institute of General Medical Sciences; Medical Research Council; Western Economic Diversification Canada; Canadian Light Source; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Biological and Environmental Research; Genentech; Office of Science; National Institutes of Health; U.S. Department of Energy","keywords":"Virology; Glycan; Antibody; Hepatitis C virus; Glycoprotein; Mechanism (biology); Neutralizing antibody; Virus; Immune escape; Hepacivirus; Biology; Chemistry; Immunology; Molecular biology; Immune system; Physics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001731792,0.0002646819,0.0001709438,0.0001042255,0.0001184083,0.0001940978,0.0001497663,0.0002021285,0.0004760131],"category_scores_gemma":[0.0001145048,0.00009361673,0.0002674084,0.000101717,0.0001211113,0.0001111666,0.0001656442,0.0003317119,0.0001678045],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001935506,"about_ca_system_score_gemma":0.00008784745,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005518873,"about_ca_topic_score_gemma":0.0004764827,"domain_scores_codex":[0.9998974,0.00001859691,0.000005735925,0.00001489344,0.00003371219,0.00002963681],"domain_scores_gemma":[0.9999447,0.000008708517,0.00002179432,0.000007809094,0.000008555723,0.000008352758],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003587232,0.00001076517,0.0006027003,0.00001245869,0.000004073522,0.00004679606,0.000009488907,0.00008748659,0.997471,0.00005266372,0.00002732807,0.001639382],"study_design_scores_gemma":[0.00001256279,0.0006257556,0.01397998,0.000007752637,0.00002210308,0.001354154,0.00003320451,0.001652097,0.9798221,0.0001004225,0.002382134,0.000007702061],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952194,0.0007522019,0.002718227,0.00006162543,0.000007735765,0.00001734741,0.00007002342,0.00003684338,0.001116689],"genre_scores_gemma":[0.9965212,0.0004808186,0.001807253,0.0001047092,0.000003824397,0.000007546676,0.0001121006,0.000008855,0.0009536501],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005518873,"threshold_uncertainty_score":0.001592398,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02531298359437138,"score_gpt":0.3362010074399077,"score_spread":0.3108880238455363,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}