{"id":"W2111243299","doi":"10.1016/j.jmb.2013.02.025","title":"Glycan Shifting on Hepatitis C Virus (HCV) E2 Glycoprotein Is a Mechanism for Escape from Broadly Neutralizing Antibodies","year":2013,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Hepatitis C virus research","field":"Medicine","cited_by":113,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Research Resources; National Research Council Canada; National Institute of General Medical Sciences; Medical Research Council; Western Economic Diversification Canada; Canadian Light Source; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Biological and Environmental Research; Genentech; Office of Science; National Institutes of Health; U.S. Department of Energy","keywords":"Virology; Glycan; Antibody; Hepatitis C virus; Glycoprotein; Mechanism (biology); Neutralizing antibody; Virus; Immune escape; Hepacivirus; Biology; Chemistry; Immunology; Molecular biology; Immune system; Physics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003949622,0.0002426703,0.0006915394,0.0003335361,0.0001052437,0.00005119647,0.0002686809,0.0002752063,0.0004568001],"category_scores_gemma":[0.0009897158,0.0001976124,0.0003167361,0.0001799413,0.0000978321,0.000102329,0.00007869175,0.0005273435,0.0000982159],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001222745,"about_ca_system_score_gemma":0.0001973471,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005243112,"about_ca_topic_score_gemma":0.000189105,"domain_scores_codex":[0.997866,0.0002260635,0.0007004954,0.0003093636,0.0003557295,0.0005423672],"domain_scores_gemma":[0.9980747,0.0002068767,0.0003881524,0.0003022037,0.0007477835,0.000280245],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003056261,0.0001055825,0.01088717,0.00004975573,0.0003728118,0.0002920908,0.0002425907,0.000001757326,0.9472733,0.002121084,0.001523946,0.03682434],"study_design_scores_gemma":[0.004064245,0.0057635,0.008758586,0.0005515285,0.0001705946,0.0001165212,0.00009153244,0.0008840373,0.9489925,0.02033913,0.00987324,0.0003945738],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9784743,0.000602303,0.01318141,0.005875798,0.0002689155,0.0007402509,0.00006896169,0.00002165302,0.0007663796],"genre_scores_gemma":[0.9738863,0.000679142,0.02097287,0.003888394,0.0003806608,0.0000422401,0.00002456406,0.00005602232,0.0000698078],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03642976,"threshold_uncertainty_score":0.8058401,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02531298359437138,"score_gpt":0.3362010074399077,"score_spread":0.3108880238455363,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}