{"id":"W2111257615","doi":"10.1086/644768","title":"Trends in Multidrug Treatment Failure and Subsequent Mortality among Antiretroviral Therapy–Experienced Patients with HIV Infection in North America","year":2009,"lang":"en","type":"article","venue":"Clinical Infectious Diseases","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; McGill University; University of Calgary; Simon Fraser University","funders":"National Institute of Allergy and Infectious Diseases; National Center for Research Resources; National Institute of Mental Health; National Institute on Alcohol Abuse and Alcoholism; Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute on Drug Abuse; U.S. Public Health Service; National Cancer Institute; National Institutes of Health","keywords":"Medicine; Regimen; Internal medicine; Proportional hazards model; Viral load; Mortality rate; Antiretroviral therapy; Immunology; Human immunodeficiency virus (HIV)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006333984,0.0003237014,0.0006278054,0.0003144387,0.00007655222,0.0000329153,0.00003634262,0.00009648397,0.00005206369],"category_scores_gemma":[0.00006853854,0.0002228072,0.0001553085,0.0006711914,0.0002382836,0.000208762,0.00001590139,0.0001764044,0.000007619288],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002837479,"about_ca_system_score_gemma":0.00008534738,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004053091,"about_ca_topic_score_gemma":0.004540105,"domain_scores_codex":[0.9981615,0.0001429151,0.0005764652,0.0005549725,0.00023237,0.0003317723],"domain_scores_gemma":[0.9991407,0.00008656035,0.0001534765,0.0002638972,0.00005540471,0.0002999744],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002531292,0.006043483,0.9322155,0.000006298563,0.0001004245,0.0001171749,0.0004539902,0.00002244286,9.342993e-7,0.000002502769,0.00004168002,0.06074248],"study_design_scores_gemma":[0.01075707,0.002956887,0.9855195,0.000052941,0.0001021944,0.00000134797,0.00004617446,0.0001193971,0.000009708079,0.00001130152,0.0001890889,0.0002344146],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987189,0.0000814925,0.000005263801,0.0001765223,0.00005993501,0.0006486804,0.00002225257,0.0001085518,0.0001784687],"genre_scores_gemma":[0.9985265,0.0005083058,0.00002509832,0.0001658219,0.00005176993,0.0001191659,0.0004096739,0.00001733592,0.0001763132],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06050806,"threshold_uncertainty_score":0.9085814,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02073094666257519,"score_gpt":0.3231218992976396,"score_spread":0.3023909526350644,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}