{"id":"W2111305780","doi":"10.1371/journal.pone.0126206","title":"An Extended Surface Loop on Toxoplasma gondii Apical Membrane Antigen 1 (AMA1) Governs Ligand Binding Selectivity","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Toxoplasma gondii Research Studies","field":"Immunology and Microbiology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC","keywords":"Isothermal titration calorimetry; Biology; Epitope; Plasma protein binding; Cell biology; Biophysics; Antigen; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001555227,0.0002164578,0.0002053171,0.00007472014,0.0001660054,0.0003750113,0.0002611662,0.0002477943,0.001287572],"category_scores_gemma":[0.0002484041,0.0001218193,0.0001779361,0.00006769778,0.0002733159,0.000250068,0.000265179,0.0004290432,0.0003847088],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000249223,"about_ca_system_score_gemma":0.0001679678,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003677182,"about_ca_topic_score_gemma":0.0006475649,"domain_scores_codex":[0.9998761,0.00001837804,0.000006993402,0.0000264076,0.0000378195,0.00003427996],"domain_scores_gemma":[0.9998844,0.00002342139,0.00003056998,0.000008039457,0.00001359416,0.00004002904],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001762378,0.00003276253,0.00139044,0.00003795583,0.000007350275,0.00014242,0.00004704636,0.0003963165,0.9960514,0.0003279875,0.00007887383,0.001311238],"study_design_scores_gemma":[0.000102573,0.0005687464,0.02745517,0.00003205161,0.00003533797,0.001274937,0.0002102875,0.01496872,0.9491193,0.0004894232,0.005702122,0.00004123558],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982327,0.0001748426,0.0007268885,0.00003427987,0.00000834412,0.000005417468,0.00003247794,0.0000268906,0.0007580868],"genre_scores_gemma":[0.9986349,0.00009145059,0.0006677406,0.00004577763,0.000003659873,0.000005807924,0.0001062382,0.000008764018,0.0004357423],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001287572,"threshold_uncertainty_score":0.004307389,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07241331875381579,"score_gpt":0.2835010016997225,"score_spread":0.2110876829459067,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}