{"id":"W2111335317","doi":"10.1093/neuonc/nou091","title":"Phase 2 study of safety and efficacy of nimotuzumab in pediatric patients with progressive diffuse intrinsic pontine glioma","year":2014,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Toronto","funders":"","keywords":"Nimotuzumab; Medicine; Adverse effect; Internal medicine; Clinical trial; Phases of clinical research; Radiation therapy; Oncology; Glioma; Surgery; Epidermal growth factor receptor; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001097655,0.000167622,0.0006748133,0.0003379747,0.00002406529,0.000002934773,0.00006437009,0.00007547724,0.00001231493],"category_scores_gemma":[0.0002916091,0.0001174426,0.00003429458,0.0004031482,0.00008330792,0.00003357372,0.00007343987,0.0001331558,0.000001442526],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006075576,"about_ca_system_score_gemma":0.00006913997,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002828536,"about_ca_topic_score_gemma":0.00004179549,"domain_scores_codex":[0.9986212,0.0001785033,0.0004650113,0.0003144872,0.0002200005,0.0002008178],"domain_scores_gemma":[0.9986417,0.0004912518,0.0003417305,0.0002697182,0.0001448795,0.0001107286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005563677,0.05846466,0.8818046,0.00006397223,0.00006959875,0.0003630958,0.0008251613,0.000002947203,0.002252518,0.00001734724,0.00003049912,0.05054197],"study_design_scores_gemma":[0.1260481,0.05686422,0.8143843,0.0000243515,0.0003824981,0.00002203147,0.00008880421,0.00001796937,0.001871579,0.000002751779,0.0002147953,0.00007850269],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980417,0.0001089436,0.000001134588,0.0001653085,0.00007279374,0.001471688,0.000007701332,0.00001418127,0.0001165755],"genre_scores_gemma":[0.9997299,0.00002610607,0.00005868561,0.00004906586,0.00005128608,0.00005019883,0.00001485447,0.00001934779,5.997608e-7],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1204845,"threshold_uncertainty_score":0.4789169,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00936498273563688,"score_gpt":0.2840825631903334,"score_spread":0.2747175804546965,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}