{"id":"W2111338227","doi":"10.1158/0008-5472.can-04-2898","title":"Proapoptotic Activity of Cell-Permeable Anti-Akt Single-Chain Antibodies","year":2005,"lang":"en","type":"article","venue":"Cancer Research","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Institute of Neurological Disorders and Stroke; National Cancer Institute","keywords":"Antibody; Chemistry; Cell; Protein kinase B; Cancer research; Cell biology; Apoptosis; Molecular biology; Biochemistry; Biology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002776217,0.0004899335,0.0003124609,0.0002342417,0.0001328439,0.0003702357,0.0003143891,0.0002709246,0.0009739255],"category_scores_gemma":[0.0001543989,0.0001874123,0.0002917993,0.0002133344,0.000121649,0.0002002566,0.0001552699,0.0006265318,0.0004170726],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004241457,"about_ca_system_score_gemma":0.000225209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002903853,"about_ca_topic_score_gemma":0.0005882852,"domain_scores_codex":[0.9996849,0.00003995241,0.00003122621,0.00006151506,0.0001086544,0.00007366532],"domain_scores_gemma":[0.9998668,0.0000262282,0.00002846762,0.00001603081,0.00003681476,0.00002558891],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005065122,0.00005024913,0.0002090661,0.00004515727,0.000008654285,0.00003031189,0.000008706363,0.00009411071,0.996594,0.0001274408,0.00008917262,0.002692477],"study_design_scores_gemma":[0.00001738652,0.0002626923,0.001495375,0.000005147303,0.00001867617,0.0002635685,0.000006543852,0.0009083979,0.993203,0.00002538518,0.003790791,0.000002910204],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9780414,0.004955807,0.01337053,0.0001873942,0.0000910531,0.00009917514,0.0004919281,0.0001818248,0.002580819],"genre_scores_gemma":[0.9794207,0.003509948,0.01145854,0.0001302878,0.00003055166,0.00009344466,0.001523233,0.00002991117,0.003803314],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009739255,"threshold_uncertainty_score":0.003258169,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07255394647327673,"score_gpt":0.3785975475159622,"score_spread":0.3060436010426855,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}