{"id":"W2111342035","doi":"10.1186/1755-8417-2-4","title":"Abnormal autophagy, ubiquitination, inflammation and apoptosis are dependent upon lysosomal storage and are useful biomarkers of mucopolysaccharidosis VI","year":2009,"lang":"en","type":"article","venue":"PathoGenetics","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":107,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Regione Campania; Fondazione Telethon; European Commission","keywords":"Autophagy; Lysosome; Dermatan sulfate; Mucopolysaccharidosis; Cell biology; Inflammation; Intracellular; Lysosomal storage disease; Biology; Apoptosis; Chemistry; Immunology; Biochemistry; Cell; Heparan sulfate; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003272224,0.0002326364,0.0003778494,0.0003121283,0.0001295774,0.0000494122,0.0001120648,0.0001884521,0.00004796634],"category_scores_gemma":[0.0002773723,0.0002306053,0.00006679817,0.0003185931,0.0001126243,0.0001290072,0.00009576671,0.000162583,0.00000456982],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000882719,"about_ca_system_score_gemma":0.00007083405,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000238711,"about_ca_topic_score_gemma":0.0000340906,"domain_scores_codex":[0.9980897,0.0001039663,0.000437317,0.0003875345,0.0006324474,0.0003490931],"domain_scores_gemma":[0.9987639,0.00006020346,0.0002819725,0.0003052889,0.0003438242,0.000244812],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00042957,0.0003375001,0.3709874,0.0005820818,0.0001719611,0.00009916817,0.001115487,0.00006767803,0.5533065,0.0001250378,0.0001092593,0.0726684],"study_design_scores_gemma":[0.001672764,0.0004727886,0.7833505,0.0001375678,0.0001366168,0.00006033531,0.0006964466,0.002270266,0.2107876,0.0001024679,0.00009214412,0.0002204625],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956586,0.002123874,0.0004799606,0.0008097051,0.00006018843,0.0005541015,0.00005981772,0.00005170726,0.0002020655],"genre_scores_gemma":[0.9976127,0.0007965699,0.001290177,0.00008404421,0.0000855857,0.0000188635,0.00003082307,0.00002720456,0.00005402359],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4123631,"threshold_uncertainty_score":0.9403813,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01642375311141786,"score_gpt":0.2669375111556962,"score_spread":0.2505137580442783,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}