{"id":"W2111342035","doi":"10.1186/1755-8417-2-4","title":"Abnormal autophagy, ubiquitination, inflammation and apoptosis are dependent upon lysosomal storage and are useful biomarkers of mucopolysaccharidosis VI","year":2009,"lang":"en","type":"article","venue":"PathoGenetics","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":107,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Regione Campania; Fondazione Telethon; European Commission","keywords":"Autophagy; Lysosome; Dermatan sulfate; Mucopolysaccharidosis; Cell biology; Inflammation; Intracellular; Lysosomal storage disease; Biology; Apoptosis; Chemistry; Immunology; Biochemistry; Cell; Heparan sulfate; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002717553,0.0004686098,0.00024387,0.0008063963,0.0001753858,0.0002548387,0.0001207119,0.0002264849,0.0008794617],"category_scores_gemma":[0.0002509802,0.00008546036,0.0001797291,0.0003308062,0.0003137433,0.0002215078,0.0002438649,0.0002526996,0.0001467452],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002825616,"about_ca_system_score_gemma":0.0001524902,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002000905,"about_ca_topic_score_gemma":0.0002782457,"domain_scores_codex":[0.9997898,0.00004394799,0.00004261763,0.00003179118,0.00006136302,0.00003049285],"domain_scores_gemma":[0.9997725,0.00002273152,0.0001294106,0.00001301277,0.00003036927,0.00003193082],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001634164,0.0001130619,0.06303331,0.0005081037,0.00007191236,0.002029732,0.00009462686,0.0001529249,0.9188414,0.0003435752,0.0001606673,0.01301659],"study_design_scores_gemma":[0.00003989777,0.00148797,0.2810582,0.00006316372,0.0001293531,0.01435009,0.0001920424,0.0004869196,0.6988708,0.000614592,0.002685943,0.00002097186],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890146,0.006751813,0.002035883,0.00006947088,0.00002329721,0.00004999268,0.0005526046,0.0000734477,0.001428867],"genre_scores_gemma":[0.9951465,0.00196454,0.001940301,0.00002270888,0.0000114283,0.00003825385,0.0003599745,0.000003903623,0.0005124692],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008794617,"threshold_uncertainty_score":0.002942085,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01642375311141786,"score_gpt":0.2669375111556962,"score_spread":0.2505137580442783,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}