{"id":"W2111347432","doi":"10.1200/jco.2009.23.1910","title":"Intensive Loading Dose of Trastuzumab Achieves Higher-Than-Steady–State Serum Concentrations and Is Well Tolerated","year":2009,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Charles-Le Moyne","funders":"GlaxoSmithKline","keywords":"Trastuzumab; Medicine; Regimen; Loading dose; Cardiotoxicity; Metastatic breast cancer; Internal medicine; Pharmacokinetics; Chemotherapy; Adverse effect; Breast cancer; Phases of clinical research; Oncology; Cancer; Pharmacology; Gastroenterology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001992397,0.000145571,0.00142496,0.0001429984,0.00004846729,0.00001538873,0.000159299,0.000308735,0.0004415334],"category_scores_gemma":[0.002051994,0.0001083469,0.0002637381,0.0002281201,0.0004187126,0.000130353,0.00003687966,0.001358202,0.00002172067],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001855947,"about_ca_system_score_gemma":0.001922545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001996187,"about_ca_topic_score_gemma":0.00001918275,"domain_scores_codex":[0.9963504,0.0004534099,0.002217242,0.0002110415,0.0004434451,0.0003244444],"domain_scores_gemma":[0.9951398,0.001536797,0.001126449,0.0001798659,0.001501613,0.0005154238],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.02735298,0.006154386,0.2052967,0.000329269,0.002180412,0.004765701,0.006184106,0.00009753335,0.04652753,0.000996375,0.1131494,0.5869656],"study_design_scores_gemma":[0.01814194,0.05214725,0.8048614,0.0007341625,0.0005009206,0.0009524326,0.001409414,0.0005642239,0.007979327,0.001493089,0.110961,0.0002548116],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9482951,0.0008163252,0.00007545816,0.04547055,0.0007212446,0.0002445323,0.00001227262,0.000009352378,0.00435513],"genre_scores_gemma":[0.9890291,0.00161854,0.001162606,0.006465882,0.0005445302,0.000001151714,0.000001653326,0.00001332616,0.001163178],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5995647,"threshold_uncertainty_score":0.5900788,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1793615897102089,"score_gpt":0.5111639668432632,"score_spread":0.3318023771330543,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}