{"id":"W2111378771","doi":"10.18632/oncotarget.604","title":"Disulfiram, a drug widely used to control alcoholism, suppresses self-renewal of glioblastoma and overrides resistance to temozolomide","year":2012,"lang":"en","type":"article","venue":"Oncotarget","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":139,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; Vancouver General Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research; Hannah's Heroes Foundation","keywords":"Temozolomide; Medicine; Disulfiram; Cancer; Brain tumor; Drug resistance; Internal medicine; Glioblastoma; Oncology; Pharmacology; Cancer research; Psychiatry; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002205943,0.0002565289,0.0006134376,0.0001582513,0.00006635856,0.00002437362,0.00009676381,0.00006770738,0.00006747455],"category_scores_gemma":[0.0002138118,0.0002057091,0.0001044301,0.0002539347,0.00004262454,0.0001360656,0.00006694241,0.00007526759,0.00005280713],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000103851,"about_ca_system_score_gemma":0.00005805893,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002253847,"about_ca_topic_score_gemma":0.0005474719,"domain_scores_codex":[0.9984139,0.00005577672,0.0003627172,0.0003229352,0.0003577583,0.0004868833],"domain_scores_gemma":[0.9984764,0.000282938,0.0001051483,0.000395099,0.0001104588,0.0006298875],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001778674,0.001567416,0.8920323,0.0001709923,0.0004177986,0.00008662101,0.003971172,0.00002171673,0.0475363,0.0008372355,0.0514398,0.000140031],"study_design_scores_gemma":[0.009224779,0.001116346,0.6056736,0.0004872731,0.0006721659,0.00004847698,0.0003736894,0.00001908286,0.2733816,0.0001831232,0.1083182,0.0005016031],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921784,0.001738924,0.00002236422,0.004149112,0.0001755211,0.0008281986,0.0001374743,0.00007604905,0.0006939031],"genre_scores_gemma":[0.995162,0.00003398243,0.003261705,0.0008537127,0.0001974186,0.0001418292,0.00001042918,0.00003821123,0.000300708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2863587,"threshold_uncertainty_score":0.8388572,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01119480273863483,"score_gpt":0.2717286664799543,"score_spread":0.2605338637413194,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}