{"id":"W2111383131","doi":"10.1021/ja511204p","title":"Structural Basis of Ligand Binding to UDP-Galactopyranose Mutase from <i>Mycobacterium tuberculosis</i> Using Substrate and Tetrafluorinated Substrate Analogues","year":2015,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Fonds pour la Formation à la Recherche dans l’Industrie et dans l’Agriculture; Western Economic Diversification Canada; Interreg; European Commission; Natural Sciences and Engineering Research Council of Canada; University of Southampton; Fonds De La Recherche Scientifique - FNRS; Canadian Institutes of Health Research","keywords":"Mutase; Chemistry; Stereochemistry; Ligand (biochemistry); Flavin group; Substrate (aquarium); Enzyme; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002485352,0.000301987,0.0007192628,0.00002607762,0.00008368639,0.00007633449,0.0004462387,0.00013638,0.00004070179],"category_scores_gemma":[0.0002220477,0.0002213004,0.0005202538,0.000458707,0.0004740832,0.0001647739,0.0001520781,0.0004901929,7.600515e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000235363,"about_ca_system_score_gemma":0.0001385774,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003336047,"about_ca_topic_score_gemma":0.000003048329,"domain_scores_codex":[0.9981596,0.00004025597,0.0007033844,0.0002767835,0.0004745643,0.0003453686],"domain_scores_gemma":[0.9978488,0.0002191924,0.0009274156,0.0003271609,0.0002590437,0.0004183935],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002022078,0.00004293501,0.02396616,0.00005357861,0.0003063545,0.00001087467,0.0008098153,0.00004270131,0.9741132,3.692685e-7,0.0002198376,0.0002319287],"study_design_scores_gemma":[0.0005685098,0.00002739282,0.002032188,0.0001552539,0.0002917087,0.00009486777,0.002092973,0.0003234626,0.994062,0.00005888355,0.00003855607,0.0002542161],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99907,0.000171875,0.000003986364,0.000307205,0.0001028963,0.00003870327,0.0002124437,0.0000157081,0.00007719821],"genre_scores_gemma":[0.9983331,0.00006393522,0.001112776,0.0001089992,0.0003255627,0.000001055097,0.00001187577,0.00002893024,0.00001377192],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02193397,"threshold_uncertainty_score":0.9024369,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02314427653978728,"score_gpt":0.2505421899459535,"score_spread":0.2273979134061662,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}