{"id":"W2111419151","doi":"10.1186/bcr3058","title":"Inhibition of cathepsin B activity attenuates extracellular matrix degradation and inflammatory breast cancer invasion","year":2011,"lang":"en","type":"article","venue":"Breast Cancer Research","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":114,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Windsor","funders":"National Cancer Institute, Cairo University; Ain Shams University; National Cancer Institute; National Institutes of Health; Wayne State University; Barbara Ann Karmanos Cancer Institute; Avon Foundation for Women; Fogarty International Center; Cairo University; U.S. Department of Defense","keywords":"Surgical oncology; Breast cancer; Extracellular matrix; Medicine; Cancer research; Cathepsin S; Cathepsin; Cathepsin B; Cancer; Internal medicine; Oncology; Chemistry; Biology; Cell biology; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005750377,0.0001390336,0.0001382677,0.0001167815,0.0001279123,0.00001882216,0.0001162876,0.000170699,0.0001622176],"category_scores_gemma":[0.00001668975,0.0001286683,0.00004897998,0.0001566329,0.0001739539,0.00002881145,0.0001750713,0.0001869682,0.000005941357],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005920122,"about_ca_system_score_gemma":0.0002651776,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00299042,"about_ca_topic_score_gemma":0.0003650586,"domain_scores_codex":[0.9986234,0.0001808738,0.0001788001,0.0003753807,0.000330191,0.0003113812],"domain_scores_gemma":[0.9991566,0.00000967757,0.00009789943,0.0002766353,0.0003395483,0.0001196259],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005560064,0.00009289158,0.008108866,0.000102504,0.00002757333,0.000004299975,0.0001003493,0.000001518308,0.9775997,0.0001795092,0.0002352192,0.0129915],"study_design_scores_gemma":[0.0004538689,0.00009416025,0.03348617,0.0001431437,0.0000127414,0.00004541296,0.00007210545,0.00004175408,0.9651031,0.0002181618,0.0001846783,0.0001446904],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965349,0.002318924,0.0001476185,0.0002165104,0.00006382119,0.0003607252,0.0002500698,0.00001057769,0.00009688989],"genre_scores_gemma":[0.9980406,0.001068793,0.00008311568,0.00001135744,0.0002249237,0.0001709923,0.00003170742,0.0000263307,0.0003421678],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02537731,"threshold_uncertainty_score":0.524694,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04459831296354219,"score_gpt":0.3191754410681208,"score_spread":0.2745771281045787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}