{"id":"W2111419151","doi":"10.1186/bcr3058","title":"Inhibition of cathepsin B activity attenuates extracellular matrix degradation and inflammatory breast cancer invasion","year":2011,"lang":"en","type":"article","venue":"Breast Cancer Research","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":114,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Windsor","funders":"National Cancer Institute, Cairo University; Ain Shams University; National Cancer Institute; National Institutes of Health; Wayne State University; Barbara Ann Karmanos Cancer Institute; Avon Foundation for Women; Fogarty International Center; Cairo University; U.S. Department of Defense","keywords":"Surgical oncology; Breast cancer; Extracellular matrix; Medicine; Cancer research; Cathepsin S; Cathepsin; Cathepsin B; Cancer; Internal medicine; Oncology; Chemistry; Biology; Cell biology; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001527343,0.0003574384,0.0004435321,0.0002274715,0.0001324836,0.000299825,0.0002514036,0.0002320167,0.001842487],"category_scores_gemma":[0.0001462546,0.0001242447,0.0003136311,0.0001970591,0.0001823183,0.0001058303,0.0001986009,0.0006459185,0.0003379298],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002279079,"about_ca_system_score_gemma":0.0003499143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009171832,"about_ca_topic_score_gemma":0.001383083,"domain_scores_codex":[0.9998568,0.00002444163,0.00001539014,0.0000152604,0.00003786062,0.00005017785],"domain_scores_gemma":[0.9999048,0.00002031263,0.00002182238,0.00001350843,0.00001138032,0.00002831507],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008098421,0.0002687855,0.0002696514,0.0001336427,0.00002678442,0.00004486727,0.00001503657,0.00006617174,0.9946715,0.00005457433,0.0001565984,0.003482481],"study_design_scores_gemma":[0.0001801331,0.002834519,0.007342073,0.00001582728,0.00005831209,0.0004330167,0.00003559441,0.0009769513,0.9844294,0.00002775482,0.003660458,0.000005989551],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932112,0.003743838,0.0007599017,0.0001216165,0.00004083589,0.00004114455,0.0003368917,0.00008299886,0.001661567],"genre_scores_gemma":[0.9936481,0.002371933,0.001149027,0.00006554621,0.00001413554,0.0000590317,0.0007884682,0.00001461664,0.001889077],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001842487,"threshold_uncertainty_score":0.006163776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04459831296354219,"score_gpt":0.3191754410681208,"score_spread":0.2745771281045787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}