{"id":"W2111434929","doi":"10.1534/g3.112.004754","title":"<i>Saccharomyces cerevisiae</i>Genetics Predicts Candidate Therapeutic Genetic Interactions at the Mammalian Replication Fork","year":2013,"lang":"en","type":"article","venue":"G3 Genes Genomes Genetics","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Terry Fox Foundation; National Cancer Institute; National Institutes of Health; Michael Smith Health Research BC","keywords":"Replication (statistics); Genetics; Saccharomyces cerevisiae; Fork (system call); Biology; Gene; Computer science; Virology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001930889,0.0004868394,0.0002901944,0.00009221458,0.0004270947,0.0001697842,0.0007906582,0.0002167868,0.0003190765],"category_scores_gemma":[0.000009829412,0.0004207783,0.00022774,0.0002611626,0.0001869756,0.000009907695,0.0004866694,0.000182435,0.0002768204],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007314882,"about_ca_system_score_gemma":0.0001043912,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005502061,"about_ca_topic_score_gemma":0.0002857119,"domain_scores_codex":[0.9972192,0.0001157851,0.0006314545,0.0009561743,0.0003351194,0.0007422892],"domain_scores_gemma":[0.9970271,0.00003998241,0.0002292501,0.00220959,0.0002333333,0.0002607722],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001933271,0.00004209964,0.01451566,0.00004508065,0.000160308,0.000001485107,0.0001685494,0.00606764,0.4048747,0.000009447943,0.003458939,0.5706367],"study_design_scores_gemma":[0.0004916866,0.0003282861,0.02404965,0.00001627954,0.0001585797,0.0001367672,0.0001987055,0.001834966,0.2651757,0.0001330384,0.7068313,0.0006450089],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5605342,0.4275324,0.007945047,0.000831748,0.0007461084,0.001345935,0.00008052585,0.00007007401,0.0009139195],"genre_scores_gemma":[0.9000032,0.09049905,0.002819971,0.000694807,0.0009095406,0.0004081032,0.0002944926,0.0001291893,0.004241666],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7033724,"threshold_uncertainty_score":0.9998244,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01068850556172525,"score_gpt":0.2819280830686184,"score_spread":0.2712395775068931,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}