{"id":"W2111462305","doi":"10.1093/hmg/ddt581","title":"A large-scale assessment of two-way SNP interactions in breast cancer susceptibility using 46 450 cases and 42 461 controls from the breast cancer association consortium","year":2013,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; University of Toronto; University Health Network; Centre hospitalier universitaire de Québec; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Medical Research and Materiel Command; National Cancer Institute; Universitätsklinikum Hamburg-Eppendorf; CHIST-ERA; Cancer Council Tasmania; Medical Research Council; Canadian Institutes of Health Research; U.S. Army; National Institutes of Health; Rheinische Friedrich-Wilhelms-Universität Bonn; Ministero dello Sviluppo Economico; Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail; Institut National Du Cancer; National Health and Medical Research Council; Oulun Yliopisto; Deutsche Krebshilfe; Medizinischen Hochschule Hannover; Norges Forskningsråd; Vetenskapsrådet; Stockholms Läns Landsting; Kuopion Yliopistollinen Sairaala; Karolinska Institutet; Ovarian Cancer Research Fund; Bundesministerium für Bildung und Forschung; Ministerio de Economía y Competitividad; Cancerfonden; King's College London; Academy of Finland; Agence Nationale de la Recherche; Robert Bosch Stiftung; National Breast Cancer Foundation; European Commission; Breast Cancer Research Foundation; University of Cambridge; KWF Kankerbestrijding; Herlev Hospital; University of Southern California; Fondation du cancer du sein du Québec; Wellcome Trust; Associazione Italiana per la Ricerca sul Cancro; Beckman Research Institute, City of Hope; Cancer Research UK; National Institute for Health and Care Research; Itä-Suomen Yliopisto; Ministère du Développement Économique, de l’Innovation et de l’Exportation; Lon V. Smith Foundation; European Social Fund; Agency for Science, Technology and Research; Deutsche Gesetzliche Unfallversicherung; University of California, Irvine; David F. and Margaret T. Grohne Family Foundation; Ligue Contre le Cancer; Deutsches Krebsforschungszentrum; Helsingin ja Uudenmaan Sairaanhoitopiiri; Susan G. Komen for the Cure; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Fondation de France; Cancer Council Victoria; California Department of Public Health; Sundhed og Sygdom, Det Frie Forskningsråd; Mayo Clinic; U.S. Department of Health and Human Services; Instituto de Salud Carlos III; Ohio State University","keywords":"Breast cancer; Biology; SNP; Oncology; Cancer; Internal medicine; Scale (ratio); Association (psychology); Single-nucleotide polymorphism; Genetics; Genotype; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003994966,0.0002167225,0.0003487533,0.00004301189,0.0001638874,0.00004360628,0.0001698514,0.0001590648,0.0002833797],"category_scores_gemma":[0.00007296101,0.0001911802,0.0001166167,0.0001049366,0.0001168628,0.000008038119,0.0001631744,0.0001949854,0.000001700271],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001799578,"about_ca_system_score_gemma":0.0001569695,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00826568,"about_ca_topic_score_gemma":0.01370473,"domain_scores_codex":[0.9980214,0.0004414546,0.0005308724,0.0004432579,0.0001769007,0.0003861129],"domain_scores_gemma":[0.9986064,0.0001293438,0.0004209749,0.0004094194,0.0003476607,0.00008614943],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000007191369,0.00008340599,0.6345065,0.000005494224,0.0001153433,9.107515e-7,0.00007990435,0.001431462,0.3632752,0.00001362563,0.0002974994,0.0001834963],"study_design_scores_gemma":[0.001029393,0.00003836664,0.9906399,0.0000308077,0.0001297127,0.00001464912,0.0003561948,0.004962528,0.002202117,0.0002227987,0.0001709451,0.0002025637],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948099,0.001126996,0.001426304,0.0009939866,0.0001405837,0.0004655737,0.0009708285,0.000006366609,0.0000594209],"genre_scores_gemma":[0.9975043,0.0003849771,0.001018524,0.0005853018,0.000174856,0.0001223693,0.0001276659,0.00002653552,0.0000555056],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.361073,"threshold_uncertainty_score":0.9983383,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02252996304155847,"score_gpt":0.3428602261416751,"score_spread":0.3203302631001166,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}