{"id":"W2111462305","doi":"10.1093/hmg/ddt581","title":"A large-scale assessment of two-way SNP interactions in breast cancer susceptibility using 46 450 cases and 42 461 controls from the breast cancer association consortium","year":2013,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; University of Toronto; University Health Network; Centre hospitalier universitaire de Québec; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Medical Research and Materiel Command; National Cancer Institute; Universitätsklinikum Hamburg-Eppendorf; CHIST-ERA; Cancer Council Tasmania; Medical Research Council; Canadian Institutes of Health Research; U.S. Army; National Institutes of Health; Rheinische Friedrich-Wilhelms-Universität Bonn; Ministero dello Sviluppo Economico; Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail; Institut National Du Cancer; National Health and Medical Research Council; Oulun Yliopisto; Deutsche Krebshilfe; Medizinischen Hochschule Hannover; Norges Forskningsråd; Vetenskapsrådet; Stockholms Läns Landsting; Kuopion Yliopistollinen Sairaala; Karolinska Institutet; Ovarian Cancer Research Fund; Bundesministerium für Bildung und Forschung; Ministerio de Economía y Competitividad; Cancerfonden; King's College London; Academy of Finland; Agence Nationale de la Recherche; Robert Bosch Stiftung; National Breast Cancer Foundation; European Commission; Breast Cancer Research Foundation; University of Cambridge; KWF Kankerbestrijding; Herlev Hospital; University of Southern California; Fondation du cancer du sein du Québec; Wellcome Trust; Associazione Italiana per la Ricerca sul Cancro; Beckman Research Institute, City of Hope; Cancer Research UK; National Institute for Health and Care Research; Itä-Suomen Yliopisto; Ministère du Développement Économique, de l’Innovation et de l’Exportation; Lon V. Smith Foundation; European Social Fund; Agency for Science, Technology and Research; Deutsche Gesetzliche Unfallversicherung; University of California, Irvine; David F. and Margaret T. Grohne Family Foundation; Ligue Contre le Cancer; Deutsches Krebsforschungszentrum; Helsingin ja Uudenmaan Sairaanhoitopiiri; Susan G. Komen for the Cure; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Fondation de France; Cancer Council Victoria; California Department of Public Health; Sundhed og Sygdom, Det Frie Forskningsråd; Mayo Clinic; U.S. Department of Health and Human Services; Instituto de Salud Carlos III; Ohio State University","keywords":"Breast cancer; Biology; SNP; Oncology; Cancer; Internal medicine; Scale (ratio); Association (psychology); Single-nucleotide polymorphism; Genetics; Genotype; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02126867,0.001107743,0.001396104,0.002601071,0.001754563,0.001228337,0.001010364,0.00107959,0.001992332],"category_scores_gemma":[0.02707133,0.0008720933,0.00203564,0.003951594,0.00133496,0.0005064916,0.001855749,0.00102857,0.0003839475],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000550215,"about_ca_system_score_gemma":0.0007705123,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005740411,"about_ca_topic_score_gemma":0.01015053,"domain_scores_codex":[0.9748742,0.01614742,0.001367428,0.004898568,0.002088159,0.0006243476],"domain_scores_gemma":[0.964654,0.02294977,0.003960096,0.005806751,0.001469449,0.001159929],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00219723,0.0003212779,0.9653012,0.0002599702,0.003729156,0.001086162,0.0008052537,0.001168466,0.01075621,0.0002924794,0.0006707492,0.01341193],"study_design_scores_gemma":[0.0006144003,0.001712019,0.9842225,0.00003903959,0.002669914,0.001837488,0.0004158539,0.002469267,0.003016262,0.0005193146,0.002411184,0.00007277021],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934527,0.0007593452,0.00410147,0.00005522913,0.00001030488,0.0001548112,0.001065082,0.0000272009,0.00037385],"genre_scores_gemma":[0.9876779,0.0002506528,0.008862816,0.00008514947,0.00002081522,0.0002938995,0.002551844,0.00002293426,0.00023399],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02126867,"threshold_uncertainty_score":0.1124808,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02252996304155847,"score_gpt":0.3428602261416751,"score_spread":0.3203302631001166,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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