{"id":"W2111465038","doi":"10.3747/co.21.1782","title":"Access to Personalized Medicine: Factors Influencing the Use and Value of Gene Expression Profiling in Breast Cancer Treatment","year":2014,"lang":"en","type":"article","venue":"Current Oncology","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Joseph’s Healthcare Hamilton; University of Calgary; McMaster University; Princess Margaret Cancer Centre; Health Sciences Centre; Sunnybrook Health Science Centre; University of Toronto; St. Michael's Hospital","funders":"Canada Research Chairs; Canadian Centre for Applied Research in Cancer Control; Cancer Care Ontario","keywords":"Medicine; Breast cancer; Gatekeeping; Personalized medicine; Profiling (computer programming); Family medicine; Anxiety; Oncology; Internal medicine; Cancer; Bioinformatics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001416568,0.0001171643,0.0001820515,0.00005840291,0.00005082116,0.000009583203,0.0001450595,0.00007819197,0.00001757893],"category_scores_gemma":[0.0000907328,0.00007368294,0.00002729053,0.00009525932,0.0001304821,0.000007196736,0.00009161072,0.00006007663,3.017596e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001803384,"about_ca_system_score_gemma":0.0001732758,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002071124,"about_ca_topic_score_gemma":0.0001263938,"domain_scores_codex":[0.9991603,0.0001483337,0.0001973275,0.0002591706,0.00008130504,0.0001535291],"domain_scores_gemma":[0.9995046,0.00006879565,0.00009940193,0.00018979,0.00008344751,0.00005399245],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00011988,0.00006749739,0.4018705,0.00002539543,0.00002436334,2.78131e-7,0.001925237,0.0008844521,0.5739287,0.00003087041,0.0004659802,0.02065689],"study_design_scores_gemma":[0.002571508,0.0005517954,0.3509578,0.0001566029,0.00007092891,0.00001357577,0.0008678338,0.0004599114,0.5829417,0.00003747094,0.06113823,0.0002326546],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967139,0.001318742,0.0005208509,0.0007238361,0.0003752959,0.0002935646,0.00002900056,0.000003705736,0.00002109409],"genre_scores_gemma":[0.998318,0.0006002283,0.0005132783,0.0001724978,0.0002037221,0.0001402719,0.00002893294,0.00001110493,0.00001197499],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06067225,"threshold_uncertainty_score":0.3004703,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09773053839041931,"score_gpt":0.4100031684593846,"score_spread":0.3122726300689653,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}