{"id":"W2111466280","doi":"10.1007/s00109-005-0034-0","title":"Quantitative assessment of DNA methylation: potential applications for disease diagnosis, classification, and prognosis in clinical settings","year":2006,"lang":"en","type":"review","venue":"Journal of Molecular Medicine","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":103,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Cancer Institute; National Institutes of Health; University Health Network; Fondation contre le Cancer; National Institute of Dental and Craniofacial Research; Foundation for Women's Cancer","keywords":"Epigenome; DNA methylation; Epigenetics; Disease; Biology; Computational biology; Mechanism (biology); Bioinformatics; Clinical significance; Human genetics; Methylation; Genetics; DNA; Medicine; Gene; Pathology; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001744911,0.0002217879,0.000989665,0.0002370912,0.00003387018,0.00001025675,0.0001799516,0.0002443272,0.000002584578],"category_scores_gemma":[0.0004732673,0.0001758022,0.0003714219,0.00019916,0.000168577,0.000005326769,0.00004140919,0.0002118969,1.033125e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000280892,"about_ca_system_score_gemma":0.0003928221,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000210091,"about_ca_topic_score_gemma":0.000001648821,"domain_scores_codex":[0.9971019,0.0003537953,0.001809352,0.0003112078,0.0002926378,0.0001310998],"domain_scores_gemma":[0.9969224,0.000227856,0.00197027,0.0002188041,0.0005258208,0.000134842],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001117884,0.0008260107,0.004662252,0.009548132,0.000723725,0.00002480827,0.00002298228,0.00009010037,0.01165298,0.001231492,0.0008759136,0.9702298],"study_design_scores_gemma":[0.002030802,0.002282022,0.01198212,0.004826994,0.003097762,0.00001454083,0.00005017403,0.0002100738,0.0007627632,0.00101379,0.9733243,0.0004046543],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002353078,0.9243743,0.07157872,0.0004072667,0.0001104066,0.00109961,0.00004619926,0.000001462355,0.00002897874],"genre_scores_gemma":[0.01159775,0.9764956,0.01072008,0.00003120053,0.0004031477,0.0002644171,0.0004433246,0.00003362066,0.00001086961],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9724484,"threshold_uncertainty_score":0.7169004,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06059329157942301,"score_gpt":0.4455196908247365,"score_spread":0.3849263992453135,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}