{"id":"W2111468080","doi":"10.1242/dmm.002451","title":"Mouse models of Huntington disease: variations on a theme","year":2009,"lang":"en","type":"article","venue":"Disease Models & Mechanisms","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"","keywords":"Huntington's disease; Huntingtin; Phenotype; Biology; Huntingtin Protein; Disease; Genetically modified mouse; Context (archaeology); Translation (biology); Human disease; Gene; Genetics; Neuroscience; Transgene; Mutant; Computational biology; Messenger RNA; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001229655,0.0004232258,0.0003293089,0.0002364852,0.0002675907,0.00008658509,0.0006159148,0.00005519526,0.00009209663],"category_scores_gemma":[0.0003366006,0.0004093768,0.0003011338,0.0003860242,0.00007527527,0.0004374421,0.0001013947,0.0001472217,0.00004525538],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004647709,"about_ca_system_score_gemma":0.0002330754,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005025855,"about_ca_topic_score_gemma":6.215173e-7,"domain_scores_codex":[0.9966463,0.0002674207,0.0004620244,0.001037386,0.001035817,0.0005509886],"domain_scores_gemma":[0.9976097,0.0001222301,0.0002231584,0.001092576,0.0001483454,0.000804024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0002412204,0.0008722743,0.00000281756,0.00001901684,0.000005340938,0.000009126172,0.0001088862,0.1677886,0.3030218,0.527438,0.00007937665,0.0004134759],"study_design_scores_gemma":[0.0003543086,0.0001049715,0.0001486402,0.00002764247,0.00006844622,1.389192e-7,0.00000866294,0.2208735,0.374404,0.4037584,0.000005534683,0.0002457736],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7070173,0.00006284556,0.2882739,0.0008791671,0.0001697995,0.0009334246,0.0009256706,0.0002890016,0.001448901],"genre_scores_gemma":[0.9946655,0.0000493779,0.001255684,0.003287769,0.00005993513,0.000115307,0.00004225557,0.0000628273,0.0004613478],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2876482,"threshold_uncertainty_score":0.9998358,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04345117463445145,"score_gpt":0.2647027665909699,"score_spread":0.2212515919565185,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}