{"id":"W2111468080","doi":"10.1242/dmm.002451","title":"Mouse models of Huntington disease: variations on a theme","year":2009,"lang":"en","type":"article","venue":"Disease Models & Mechanisms","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"","keywords":"Huntington's disease; Huntingtin; Phenotype; Biology; Huntingtin Protein; Disease; Genetically modified mouse; Context (archaeology); Translation (biology); Human disease; Gene; Genetics; Neuroscience; Transgene; Mutant; Computational biology; Messenger RNA; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002289907,0.001398951,0.001009881,0.003245738,0.0007077934,0.001456844,0.002107387,0.002239158,0.003605355],"category_scores_gemma":[0.0007765512,0.0008287826,0.001311294,0.00141418,0.001080754,0.001379417,0.001873899,0.003901325,0.002587747],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005893638,"about_ca_system_score_gemma":0.0004553487,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000588907,"about_ca_topic_score_gemma":0.001422919,"domain_scores_codex":[0.9986076,0.0002817933,0.0002836927,0.0002271241,0.0004659554,0.0001339109],"domain_scores_gemma":[0.998894,0.0002154539,0.0001716487,0.0003554918,0.0001820213,0.0001813435],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008758935,0.0006131154,0.000945716,0.0005767188,0.0001062834,0.0004241777,0.0003123449,0.0002519464,0.9326476,0.01435114,0.007655669,0.04123946],"study_design_scores_gemma":[0.0008796721,0.003216474,0.01200473,0.0007581027,0.0007166376,0.01003459,0.0002400323,0.002069547,0.5352063,0.01555821,0.4189762,0.000339573],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.3765247,0.1131481,0.3782979,0.02268799,0.005431972,0.004392052,0.01855753,0.01504656,0.06591324],"genre_scores_gemma":[0.3503901,0.1256304,0.3799451,0.01072735,0.001913184,0.0101288,0.02322268,0.004093196,0.09394902],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.003605355,"threshold_uncertainty_score":0.01211035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04345117463445145,"score_gpt":0.2647027665909699,"score_spread":0.2212515919565185,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}