{"id":"W2111479968","doi":"10.1200/jco.2006.06.7835","title":"Elderly Patients Benefit From Second-Line Cytotoxic Chemotherapy: A Subset Analysis of a Randomized Phase III Trial of Pemetrexed Compared With Docetaxel in Patients With Previously Treated Advanced Non–Small-Cell Lung Cancer","year":2006,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":147,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Eli Lilly and Company","keywords":"Docetaxel; Pemetrexed; Medicine; Tolerability; Internal medicine; Neutropenia; Chemotherapy; Lung cancer; Oncology; Febrile neutropenia; Population; Toxicity; Surgery; Adverse effect; Cisplatin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008026998,0.0002771832,0.005216251,0.000520002,0.00002553406,0.000006584008,0.0001430409,0.000218082,0.0002937281],"category_scores_gemma":[0.0001878344,0.0001641064,0.0007772594,0.0008398654,0.0001807129,0.0001114283,0.00001350016,0.0003604142,2.246212e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002958863,"about_ca_system_score_gemma":0.001096675,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001526933,"about_ca_topic_score_gemma":0.004590672,"domain_scores_codex":[0.9948571,0.0003092581,0.003760675,0.0003090105,0.0005084256,0.0002555523],"domain_scores_gemma":[0.9919087,0.001253492,0.005178091,0.0002655517,0.001192721,0.000201486],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6161355,0.01597285,0.3538099,0.00003440249,0.007469377,0.00002299963,0.000271358,0.0008314141,0.00005889134,6.348797e-7,0.00004512113,0.005347537],"study_design_scores_gemma":[0.7034489,0.02316945,0.2561204,0.0002253362,0.01587073,4.880933e-7,0.00003565856,0.0007337789,0.000231986,0.00000747131,0.0000448871,0.0001109553],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961643,0.0003544418,0.00016192,0.000152764,0.0001434443,0.002585906,0.0002262147,0.000005878494,0.000205169],"genre_scores_gemma":[0.9967644,0.0001811317,0.002178339,0.0001647336,0.0001129907,0.00008494619,0.0003509684,0.00002767518,0.0001348187],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09768946,"threshold_uncertainty_score":0.6692065,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02282379912447964,"score_gpt":0.3976881623197988,"score_spread":0.3748643631953192,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}