{"id":"W2111485737","doi":"10.1158/0008-5472.can-11-2739","title":"Targeting Protein Synthesis in a Myc/mTOR-Driven Model of Anorexia-Cachexia Syndrome Delays Its Onset and Prolongs Survival","year":2011,"lang":"en","type":"article","venue":"Cancer Research","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"Cachexia; Anorexia; PI3K/AKT/mTOR pathway; Medicine; Cytokine; Weight loss; Cancer; Cancer research; Endocrinology; Phenotype; Skeletal muscle; Internal medicine; Biology; Obesity; Signal transduction; Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005568388,0.0001119677,0.0001832283,0.00009575415,0.00006933564,0.000005542877,0.0002236966,0.0001744093,0.00005465043],"category_scores_gemma":[0.0002259826,0.0001068964,0.00003484826,0.0001388287,0.0002491306,0.000007218747,0.0001962136,0.000213896,0.000003034253],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001815955,"about_ca_system_score_gemma":0.0002116542,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003718195,"about_ca_topic_score_gemma":0.0001819497,"domain_scores_codex":[0.9986901,0.0002277542,0.0001767554,0.0003680575,0.0001557368,0.0003815797],"domain_scores_gemma":[0.9995016,0.00002647157,0.00004692702,0.0002132785,0.000133209,0.00007845178],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007628373,0.0001086442,0.01705721,0.0001663495,0.00004384885,0.000006987615,0.0003823579,0.0002438106,0.9806533,0.000107179,0.000111844,0.0003556476],"study_design_scores_gemma":[0.001532287,0.001110413,0.05198861,0.0002762208,0.0000231461,0.000009363866,0.0008397076,0.007288285,0.9343072,0.001887305,0.0001188699,0.0006186415],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979934,0.0009512691,0.00004397302,0.00005691547,0.00001550633,0.0004291418,0.00004044467,0.000005050706,0.0004643539],"genre_scores_gemma":[0.998847,0.0002874661,0.0002430067,0.0000139831,0.00001844655,0.0004400941,0.00001370896,0.00001903861,0.0001172537],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04634613,"threshold_uncertainty_score":0.4359109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08649127049100554,"score_gpt":0.3353709732935846,"score_spread":0.2488797028025791,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}