{"id":"W2111493068","doi":"10.1155/2012/634214","title":"Untethering the Nuclear Envelope and Cytoskeleton: Biologically Distinct Dystonias Arising from a Common Cellular Dysfunction","year":2012,"lang":"en","type":"article","venue":"International Journal of Cell Biology","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"National Institute of Neurological Disorders and Stroke; Canadian Institutes of Health Research; National Institutes of Health; Universiteit van Amsterdam; Dystonia Medical Research Foundation","keywords":"Dystonia; Endoplasmic reticulum; Neuroscience; Neurodegeneration; Biology; Phenotype; Cytoskeleton; Mutation; Cell biology; NLS; Gene; Bioinformatics; Nuclear localization sequence; Genetics; Medicine; Pathology; Disease; Nucleus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009927222,0.0005936326,0.0003237934,0.000432917,0.0002412855,0.0003374089,0.0001651245,0.0005223613,0.0006073763],"category_scores_gemma":[0.0001526312,0.0001581804,0.0002087766,0.0002269672,0.0006919701,0.0003939061,0.0005543681,0.0002507931,0.0002373362],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003630949,"about_ca_system_score_gemma":0.0002017305,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005128031,"about_ca_topic_score_gemma":0.0008095245,"domain_scores_codex":[0.9999162,0.00001295728,0.00001379072,0.00002345032,0.00001854682,0.0000150076],"domain_scores_gemma":[0.9999343,0.000007039082,0.00002696105,0.000006869429,0.000004779777,0.00002009209],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006684548,0.00003973968,0.004961133,0.0001517013,0.00002865423,0.01083983,0.0001974679,0.0002036598,0.9708368,0.002186505,0.0002427326,0.009643244],"study_design_scores_gemma":[0.0003004709,0.001471851,0.2947604,0.0001427018,0.0002683913,0.3218733,0.0009413015,0.002748315,0.3536049,0.005288198,0.01850865,0.00009151349],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990261,0.005188521,0.001799096,0.0002448349,0.00002485505,0.00001639025,0.0001399481,0.00005194846,0.002273398],"genre_scores_gemma":[0.9954383,0.001766231,0.001266766,0.0001120103,0.00001230804,0.00001325223,0.0002539648,0.00000781,0.001129344],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006073763,"threshold_uncertainty_score":0.002634466,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007687734329905676,"score_gpt":0.2296734937359483,"score_spread":0.2219857594060426,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}