{"id":"W2111521405","doi":"10.1158/1535-7163.mct-11-1014","title":"CTLA-4 Blockade Expands Infiltrating T Cells and Inhibits Cancer Cell Repopulation during the Intervals of Chemotherapy in Murine Mesothelioma","year":2012,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Toronto; University Health Network","funders":"Mesothelioma Applied Research Foundation","keywords":"Blockade; Mesothelioma; Chemotherapy; Cancer research; Repopulation; Medicine; Cancer; Biology; Oncology; Immunology; Internal medicine; Pathology; Cell biology; Receptor; Stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001515016,0.0004765681,0.0003646222,0.00044964,0.0001316961,0.0001933541,0.0002173332,0.0002536321,0.0007873361],"category_scores_gemma":[0.00009869399,0.0002142073,0.0003594319,0.0001889808,0.0001988787,0.000177442,0.0001616478,0.0009750364,0.0003060464],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002329792,"about_ca_system_score_gemma":0.0002155726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003403875,"about_ca_topic_score_gemma":0.0005708968,"domain_scores_codex":[0.9998158,0.00003075632,0.00001741158,0.00003375312,0.00003817384,0.00006423189],"domain_scores_gemma":[0.9998612,0.0000215989,0.00003760042,0.00002414141,0.00001052255,0.00004496964],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001913615,0.0001202624,0.00009597577,0.00001833535,0.000002839208,0.00003367072,0.000009682833,0.0001120102,0.9985387,0.00002609971,0.00002154796,0.0008294359],"study_design_scores_gemma":[0.00004811269,0.001822986,0.002200905,0.000004005682,0.00001937451,0.0001344737,0.00001414245,0.001313132,0.9935365,0.00003031323,0.0008729843,0.000002964308],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996309,0.0008495173,0.001593257,0.00006216941,0.00003319979,0.00004341167,0.0001981363,0.0001173144,0.0007939771],"genre_scores_gemma":[0.9944065,0.0006303025,0.002011675,0.00004090472,0.00002045933,0.00010036,0.0003506588,0.0000248506,0.002414387],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007873361,"threshold_uncertainty_score":0.002633929,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01863747007389447,"score_gpt":0.2933234176663179,"score_spread":0.2746859475924234,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}