{"id":"W2111556389","doi":"10.1002/bit.22407","title":"Auditioning of CHO host cell lines using the artificial chromosome expression (ACE) technology","year":2009,"lang":"en","type":"article","venue":"Biotechnology and Bioengineering","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Drug Research and Development; Canadian Institutes of Health Research","funders":"","keywords":"Chinese hamster ovary cell; Transfection; Cell culture; Biology; Gene; Monoclonal antibody; Gene expression; Molecular biology; Cell; Cell biology; Genetics; Computational biology; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001413827,0.0001494374,0.0001486159,0.0002001697,0.0001375249,0.00001122009,0.0002440473,0.0004862884,0.000005889429],"category_scores_gemma":[0.00003971217,0.0001175188,0.00004280207,0.000301131,0.0002463473,0.000004813941,0.0001165042,0.000227159,0.000001257684],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000010407,"about_ca_system_score_gemma":0.00002855083,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001553566,"about_ca_topic_score_gemma":0.000003794353,"domain_scores_codex":[0.9991725,0.0000182449,0.0001876339,0.0002685982,0.00007733716,0.0002756791],"domain_scores_gemma":[0.9995024,0.000009390052,0.00007035402,0.0003451421,0.00004257735,0.0000301759],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009060176,0.00003085106,0.00005118545,0.00001298174,0.00001421045,0.00000254055,0.00001016081,0.0003953874,0.9958633,0.0001569742,0.00001632683,0.003355442],"study_design_scores_gemma":[0.0001886176,0.0008029628,0.0000678065,0.00003243355,0.000009407765,0.00002711927,0.00007343665,0.00122024,0.9966795,0.00009937875,0.0006682213,0.0001308804],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887123,0.003065203,0.006198461,0.001686623,0.00006742164,0.0001850548,0.000008139575,0.0000641385,0.00001267762],"genre_scores_gemma":[0.9973372,0.000528487,0.001922936,0.00004041924,0.000122436,0.000008425537,0.000009252521,0.00001402431,0.00001684901],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00862489,"threshold_uncertainty_score":0.4792277,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01248997805515543,"score_gpt":0.2593086376119218,"score_spread":0.2468186595567664,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}