{"id":"W2111556389","doi":"10.1002/bit.22407","title":"Auditioning of CHO host cell lines using the artificial chromosome expression (ACE) technology","year":2009,"lang":"en","type":"article","venue":"Biotechnology and Bioengineering","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Drug Research and Development; Canadian Institutes of Health Research","funders":"","keywords":"Chinese hamster ovary cell; Transfection; Cell culture; Biology; Gene; Monoclonal antibody; Gene expression; Molecular biology; Cell; Cell biology; Genetics; Computational biology; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001552351,0.0006058689,0.0008455886,0.0008443889,0.0005434818,0.001255168,0.0008998167,0.0007560423,0.001860593],"category_scores_gemma":[0.001382654,0.0004616483,0.0009185641,0.0007821065,0.00048918,0.0005759471,0.001097478,0.001870186,0.002082149],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004500141,"about_ca_system_score_gemma":0.000517751,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001264274,"about_ca_topic_score_gemma":0.001941502,"domain_scores_codex":[0.9984464,0.0002971724,0.0002798223,0.0002173105,0.0006019013,0.0001573664],"domain_scores_gemma":[0.998814,0.0003101225,0.000164176,0.0003820077,0.0002634165,0.00006627367],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006242542,0.00003067699,0.0003057717,0.0000788416,0.00001127035,0.000156885,0.00006887536,0.00006317339,0.9946489,0.0004192938,0.0002061463,0.003947829],"study_design_scores_gemma":[0.00001801948,0.0001442496,0.001783076,0.00001171239,0.00003224176,0.0004930845,0.00004368355,0.0009248867,0.9799422,0.00009967132,0.01648884,0.00001840096],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5273898,0.003255466,0.4393341,0.0009615198,0.00081829,0.002729624,0.006167927,0.003362784,0.01598054],"genre_scores_gemma":[0.5765397,0.006108608,0.3594692,0.0007208165,0.0001103429,0.002545707,0.01890744,0.001566499,0.0340317],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001860593,"threshold_uncertainty_score":0.008209765,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01248997805515543,"score_gpt":0.2593086376119218,"score_spread":0.2468186595567664,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}