{"id":"W2111576030","doi":"10.1261/rna.044982.114","title":"Disparate HDV ribozyme crystal structures represent intermediates on a rugged free-energy landscape","year":2014,"lang":"en","type":"article","venue":"RNA","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; European Regional Development Fund; Natural Sciences and Engineering Research Council of Canada; Central European Institute of Technology; Grantová Agentura České Republiky; Ministerstvo Školství, Mládeže a Tělovýchovy; University of Michigan; National Institutes of Health; National Science Foundation","keywords":"Ribozyme; Hairpin ribozyme; Förster resonance energy transfer; Hammerhead ribozyme; Biology; Conformational change; Cleavage (geology); VS ribozyme; Scissile bond; Crystallography; Stereochemistry; Biophysics; Active site; RNA; Catalysis; Chemistry; Biochemistry; Fluorescence; Physics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001566437,0.0002578446,0.000416885,0.0002707867,0.0004444854,0.0007690305,0.0003963286,0.000457634,0.0009720303],"category_scores_gemma":[0.0004558998,0.0002942628,0.0002577758,0.0003116323,0.0003454219,0.0003689071,0.0003468128,0.0008111835,0.000151135],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006066181,"about_ca_system_score_gemma":0.0003332893,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001404404,"about_ca_topic_score_gemma":0.002421625,"domain_scores_codex":[0.9998829,0.00001300034,0.000007849633,0.00003411293,0.00004127389,0.00002078872],"domain_scores_gemma":[0.9998708,0.00005254726,0.00002402575,0.00001296435,0.00001978333,0.00001978103],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001040971,0.0005946868,0.03858804,0.0003989368,0.0004415792,0.001584541,0.0009046207,0.07463583,0.8346723,0.01272752,0.002670758,0.0317402],"study_design_scores_gemma":[0.0005161248,0.0007691932,0.1199424,0.0001076509,0.0004688349,0.001737705,0.001152904,0.5179738,0.3162842,0.02802712,0.01284055,0.0001794807],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992239,0.0003360621,0.005541378,0.0000989505,0.000007524129,0.00001750312,0.0002569875,0.0001782613,0.001324207],"genre_scores_gemma":[0.992736,0.0003216354,0.005328314,0.00008948637,0.000002937807,0.00003729362,0.001061649,0.00006449311,0.0003582009],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001404404,"threshold_uncertainty_score":0.004401267,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006009524849730435,"score_gpt":0.2164935518471978,"score_spread":0.2104840269974674,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}