{"id":"W2111585639","doi":"10.1111/j.1365-2036.2006.03088.x","title":"Oral V<sub>2</sub> receptor antagonist (RWJ‐351647) in patients with cirrhosis and ascites: a randomized, double‐blind, placebo‐controlled, single ascending dose study","year":2006,"lang":"en","type":"article","venue":"Alimentary Pharmacology & Therapeutics","topic":"Electrolyte and hormonal disorders","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital","funders":"","keywords":"Medicine; Cirrhosis; Tolerability; Internal medicine; Ascites; Gastroenterology; Furosemide; Free water clearance; Placebo; Diuretic; Urine osmolality; Concomitant; Vasopressin; Pharmacokinetics; Endocrinology; Pharmacology; Adverse effect; Urology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006541428,0.0005023527,0.001280176,0.0003856334,0.0002319259,0.00005435022,0.0001497139,0.0001454351,0.0001046684],"category_scores_gemma":[7.238132e-7,0.0003970848,0.0001670812,0.000391807,0.0003481814,0.0002104879,0.00006681044,0.0004829935,0.00001589769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002275194,"about_ca_system_score_gemma":0.00009627146,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002383393,"about_ca_topic_score_gemma":0.0002203733,"domain_scores_codex":[0.9970803,0.0004499358,0.0007287702,0.0006069827,0.0004274479,0.0007066148],"domain_scores_gemma":[0.9989263,0.0003576462,0.0002579245,0.0002040374,0.0001063056,0.0001478018],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7276255,0.006546016,0.1104723,0.00002356484,0.008619784,0.00004391125,0.0004975996,0.0000211886,0.1448598,0.00001259125,0.0002045368,0.00107319],"study_design_scores_gemma":[0.9334424,0.003859174,0.01595582,0.00003663,0.0136185,0.00001139877,0.0004467333,0.000176761,0.03173142,0.00004137994,0.0002218271,0.0004579552],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900525,0.001806156,0.000009470096,0.001466488,0.0001983246,0.005967862,0.00001542914,0.00007415953,0.0004096532],"genre_scores_gemma":[0.992462,0.000564878,0.0001139024,0.005900051,0.0001469158,0.000474345,0.0001958955,0.00007544638,0.0000665574],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2058169,"threshold_uncertainty_score":0.9998481,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01844251744701554,"score_gpt":0.2868652187913212,"score_spread":0.2684227013443057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}