{"id":"W2111586778","doi":"10.1016/j.cell.2012.03.036","title":"DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88","year":2012,"lang":"en","type":"article","venue":"Cell","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":594,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"National Institute of Allergy and Infectious Diseases; National Center for Research Resources; National Institute of General Medical Sciences; National Center for Advancing Translational Sciences; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Eye Institute; National Heart, Lung, and Blood Institute","keywords":"Inflammasome; Biology; Macular degeneration; RNA; Alu element; Cell biology; AIM2; Caspase 1; Ribonuclease III; Immunology; Genetics; RNA interference; Gene; Inflammation; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001861055,0.0001359204,0.00009034046,0.0000219636,0.000146585,0.00003357864,0.0000871567,0.0001613245,0.00001901726],"category_scores_gemma":[0.00001565726,0.000104716,0.00003699585,0.00005261409,0.0001292656,0.00001239641,0.0001020935,0.000106109,0.00001784233],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005050538,"about_ca_system_score_gemma":0.00001487148,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001523632,"about_ca_topic_score_gemma":0.000008132301,"domain_scores_codex":[0.9993103,0.00005778841,0.000149081,0.0001746686,0.00007008667,0.0002381138],"domain_scores_gemma":[0.9996187,0.000007599703,0.00005817086,0.0002260495,0.00002814158,0.00006135455],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001544795,0.00002371579,0.002748393,0.00001419654,0.00002894552,0.000002580038,0.0003271119,0.000008915047,0.9937178,0.00007056347,0.0003435844,0.002698727],"study_design_scores_gemma":[0.0007382313,0.0000808342,0.01373096,0.000005199874,0.00004515141,0.00002495924,0.0001376939,0.00005457988,0.9377569,0.0001242002,0.0470701,0.0002311831],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885892,0.00847382,0.0001097337,0.000183138,0.000148275,0.0001570998,0.000002065475,0.000008087237,0.002328595],"genre_scores_gemma":[0.997565,0.0008385812,0.00005778849,0.0002445585,0.0001474418,0.00001305033,0.0001005318,0.00001850399,0.001014565],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05596092,"threshold_uncertainty_score":0.4270194,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005257614715215924,"score_gpt":0.2015955656352339,"score_spread":0.196337950920018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}