{"id":"W2111676569","doi":"10.1124/dmd.32.12.","title":"USE OF A BENZYLOXY-SUBSTITUTED LACTONE CYCLOOXYGENASE-2 INHIBITOR AS A SELECTIVE FLUORESCENT PROBE FOR CYP3A ACTIVITY IN PRIMARY CULTURED RAT AND HUMAN HEPATOCYTES","year":2004,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Microsome; CYP3A; Hepatocyte; Metabolite; Enzyme inducer; Chemistry; Cytochrome P450; Glucuronidation; Enzyme; Phenobarbital; Biochemistry; Enzyme inhibitor; Molecular biology; Biology; Pharmacology; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004289405,0.0003544077,0.0005830616,0.0002202751,0.0002935432,0.00006346341,0.0001030867,0.0002589001,0.00001191134],"category_scores_gemma":[0.00005202739,0.0003298708,0.0001138065,0.0002788443,0.0002478938,0.000600222,0.00009102867,0.0004100846,0.000002069724],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006901196,"about_ca_system_score_gemma":0.0001166904,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003209437,"about_ca_topic_score_gemma":0.00009830612,"domain_scores_codex":[0.9981313,0.0003000614,0.0004314561,0.0005141608,0.0001873605,0.000435712],"domain_scores_gemma":[0.9990581,0.000136149,0.0002306408,0.0001483813,0.0001546613,0.0002720338],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001841163,0.001141205,0.002195723,0.0002133711,0.0001302665,0.00001371203,0.002108583,0.0001723953,0.9788937,0.007624188,0.0001137581,0.005551957],"study_design_scores_gemma":[0.007686368,0.00007323137,0.06307779,0.00005803597,0.000459007,0.00001646768,0.00006236909,0.0002122448,0.9197125,0.002898755,0.005345478,0.0003977701],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928909,0.003820814,0.0003918004,0.0002826362,0.0004342145,0.00168252,0.0003756486,0.00004660524,0.00007485544],"genre_scores_gemma":[0.9963154,0.001421831,0.0009091171,0.0005504937,0.000235163,0.0002710511,0.0002080612,0.00003189411,0.00005696847],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06088207,"threshold_uncertainty_score":0.9999154,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04739199934326008,"score_gpt":0.3580090161846279,"score_spread":0.3106170168413678,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}