{"id":"W2111676569","doi":"10.1124/dmd.32.12.","title":"USE OF A BENZYLOXY-SUBSTITUTED LACTONE CYCLOOXYGENASE-2 INHIBITOR AS A SELECTIVE FLUORESCENT PROBE FOR CYP3A ACTIVITY IN PRIMARY CULTURED RAT AND HUMAN HEPATOCYTES","year":2004,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Microsome; CYP3A; Hepatocyte; Metabolite; Enzyme inducer; Chemistry; Cytochrome P450; Glucuronidation; Enzyme; Phenobarbital; Biochemistry; Enzyme inhibitor; Molecular biology; Biology; Pharmacology; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004585954,0.0002722903,0.0004341947,0.0001901319,0.0003652495,0.0003292013,0.0003049419,0.0003255755,0.001212069],"category_scores_gemma":[0.0001938049,0.0002307103,0.0004525019,0.0002214952,0.0002622953,0.0002423155,0.000158212,0.0006866679,0.0003179404],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004464334,"about_ca_system_score_gemma":0.0004128351,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003146518,"about_ca_topic_score_gemma":0.005537575,"domain_scores_codex":[0.999793,0.00005507423,0.00001300299,0.00005116718,0.00003422971,0.00005357756],"domain_scores_gemma":[0.9997935,0.00009808464,0.00002052314,0.0000400738,0.00002767227,0.00002027193],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002345058,0.0000251137,0.0001209711,0.00002614806,0.000006814496,0.00005501907,0.00002109327,0.00009561397,0.9980995,0.0001858054,0.00006420682,0.001065194],"study_design_scores_gemma":[0.000009247257,0.0001084037,0.0003934382,8.543018e-7,0.00001023756,0.00006926078,0.000008929221,0.00037753,0.9985451,0.00001400927,0.0004611202,0.000001865727],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.9417354,0.003545329,0.0465215,0.000442232,0.0001808074,0.00008364376,0.0006790287,0.0003571284,0.006454844],"genre_scores_gemma":[0.9786849,0.001438501,0.0153333,0.000102758,0.00003087155,0.00007449631,0.000665484,0.00005596292,0.003613743],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.003146518,"threshold_uncertainty_score":0.006256402,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04739199934326008,"score_gpt":0.3580090161846279,"score_spread":0.3106170168413678,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}