{"id":"W2111684307","doi":"10.3899/jrheum.110621","title":"Glucosamine Sulfate Reduces Prostaglandin E<sub>2</sub>Production in Osteoarthritic Chondrocytes Through Inhibition of Microsomal PGE Synthase-1","year":2011,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Notre-Dame","funders":"","keywords":"Endocrinology; Internal medicine; Microsome; Prostaglandin E; Prostaglandin; Glutathione; Prostaglandin E2; Medicine; Stimulation; Advanced glycation end-product; Receptor; Biochemistry; Enzyme; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001838163,0.0008285769,0.0004642741,0.0002888737,0.0001347375,0.0002861824,0.0002159937,0.0002747364,0.001404556],"category_scores_gemma":[0.0001612203,0.000178707,0.0003909335,0.0001963677,0.0003961831,0.0001785442,0.0001801523,0.0004676362,0.0003677609],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003732485,"about_ca_system_score_gemma":0.0004241663,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001749069,"about_ca_topic_score_gemma":0.003149724,"domain_scores_codex":[0.9998075,0.00003952107,0.00002608153,0.0000214857,0.00005637857,0.0000490132],"domain_scores_gemma":[0.999886,0.00001103502,0.00004283412,0.000009884398,0.00002136325,0.00002893855],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005006651,0.00006028914,0.00011722,0.00009595317,0.00001139374,0.00003350514,0.00001330962,0.00003324853,0.9979466,0.00001983952,0.00002695626,0.001141004],"study_design_scores_gemma":[0.00008647232,0.001833802,0.006093483,0.00001389684,0.00003131984,0.0001224001,0.0000392446,0.0003172415,0.9899024,0.00002768158,0.001525549,0.00000646903],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911829,0.005230015,0.001622332,0.0001411081,0.00008652458,0.00006089437,0.000287293,0.0001201998,0.001268648],"genre_scores_gemma":[0.9909005,0.003304209,0.001924917,0.0001189053,0.00003760825,0.00007808732,0.000473041,0.00002008999,0.003142704],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001749069,"threshold_uncertainty_score":0.004698694,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0197004588877515,"score_gpt":0.2366632028255272,"score_spread":0.2169627439377757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}