{"id":"W2111735661","doi":"10.1093/hmg/ddq558","title":"SOX9 controls epithelial branching by activating RET effector genes during kidney development","year":2011,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":135,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Oulun Yliopisto; Medizinischen Hochschule Hannover; McGill University; European Commission; Association pour la Recherche sur le Cancer; Harvard University","keywords":"Kidney development; Biology; SOX9; Nephron; Kidney; Glial cell line-derived neurotrophic factor; Ureteric bud; Mesenchyme; Internal medicine; Zebrafish; Cell biology; Endocrinology; Genetics; Gene; Gene expression; Embryonic stem cell; Embryo; Medicine; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000127086,0.0003012035,0.0002198719,0.0000507542,0.0002803454,0.00003605364,0.0002902935,0.0002495212,0.00004181166],"category_scores_gemma":[0.00003381436,0.0002877459,0.0001332626,0.00006994107,0.00008518487,0.000004027402,0.0001478579,0.0001833307,0.00001954369],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003612481,"about_ca_system_score_gemma":0.0001051807,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001834382,"about_ca_topic_score_gemma":0.000003998679,"domain_scores_codex":[0.9984014,0.00009702561,0.0003413327,0.0004943485,0.0002171863,0.0004487137],"domain_scores_gemma":[0.9991841,0.000004508481,0.0001522267,0.0003612778,0.00006480371,0.0002330662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000697381,0.00004570023,0.0008655367,0.00004853321,0.0002103753,0.00002091558,0.0002154969,0.00006540071,0.9956036,0.00001297641,0.0002218166,0.002619906],"study_design_scores_gemma":[0.001145086,0.0001639499,0.003524085,0.00005892466,0.00003148707,0.00001718416,0.00002021674,0.00001478078,0.9823796,0.00003545924,0.01220363,0.0004056308],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924946,0.002753476,0.002861521,0.00001530165,0.0001720349,0.0002800405,0.0000199682,0.00003225959,0.001370809],"genre_scores_gemma":[0.9963334,0.0002162287,0.002292796,0.0003273427,0.0001809262,0.00004353061,0.0001554828,0.00007257998,0.0003777227],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01322404,"threshold_uncertainty_score":0.9999574,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008530871824261122,"score_gpt":0.2194540737876943,"score_spread":0.2109232019634332,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}