{"id":"W2111760472","doi":"10.1091/mbc.e03-06-0444","title":"TopBP1 and ATR Colocalization at Meiotic Chromosomes: Role of TopBP1/Cut5 in the Meiotic Recombination Checkpoint","year":2004,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"Syöpäjärjestöt; Academy of Finland","keywords":"Biology; G2-M DNA damage checkpoint; Synapsis; Homologous recombination; Meiosis; CHEK1; Cell biology; Genetics; Genetic recombination; Schizosaccharomyces pombe; DNA repair; Cell cycle checkpoint; Mutant; DNA; Cell cycle; Recombination; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003556178,0.0001431482,0.0001877169,0.0000452116,0.00005246029,0.000004469593,0.0003372021,0.0002207368,0.000007811566],"category_scores_gemma":[0.0001342178,0.00009969521,0.0001095562,0.0001420712,0.0002167975,0.000002609117,0.0002219887,0.00008020837,0.000001998312],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003842123,"about_ca_system_score_gemma":0.00005020066,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000485841,"about_ca_topic_score_gemma":0.00005827586,"domain_scores_codex":[0.9989043,0.0002419894,0.0002905563,0.0002805768,0.0001028168,0.0001797321],"domain_scores_gemma":[0.9992407,0.00001716223,0.0001936097,0.0004544682,0.00006869553,0.00002537712],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002966981,0.0001059017,0.001065769,0.00003447954,0.00002172056,0.000001212115,0.0001593054,0.0003806414,0.9960529,0.001995841,0.00001581273,0.0001367612],"study_design_scores_gemma":[0.0007642771,0.0004149913,0.001120711,0.00002149777,0.00003287319,0.00001350782,0.0001271089,0.00008493144,0.9904551,0.006190194,0.0006699491,0.0001048887],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962623,0.001338687,0.0007362863,0.0003687682,0.0001240029,0.0003984988,0.000007029843,0.000005208028,0.000759187],"genre_scores_gemma":[0.9989415,0.000111151,0.0005449514,0.0002134388,0.00001798919,0.00001476878,0.00004960019,0.00001455122,0.00009205382],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005597816,"threshold_uncertainty_score":0.4065453,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003551237391865044,"score_gpt":0.2102550627530524,"score_spread":0.2067038253611874,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}