{"id":"W2111783499","doi":"10.1136/thx.2010.146118","title":"Impact of non-linear smoking effects on the identification of gene-by-smoking interactions in COPD genetics studies","year":2010,"lang":"en","type":"article","venue":"Thorax","topic":"Chronic Obstructive Pulmonary Disease (COPD) Research","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"National Center for Research Resources; National Heart, Lung, and Blood Institute; American Thoracic Society; Amicus Therapeutics; U.S. Public Health Service; AstraZeneca; Pfizer; GlaxoSmithKline","keywords":"Medicine; COPD; Identification (biology); Genetics; Gene; Bioinformatics; Computational biology; Environmental health; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000526773,0.0001347659,0.0002898391,0.0001898575,0.00006177815,0.000008434492,0.000158383,0.00004983897,0.00006217937],"category_scores_gemma":[0.0005164952,0.00009545476,0.0001256052,0.0003463606,0.0001871826,0.00005750157,0.00006986386,0.0004521521,0.00000771993],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002313288,"about_ca_system_score_gemma":0.0001382512,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001129891,"about_ca_topic_score_gemma":0.0000366246,"domain_scores_codex":[0.9987008,0.0001047233,0.0003925805,0.0002148994,0.0003746142,0.0002124099],"domain_scores_gemma":[0.9984521,0.0005175495,0.0002019221,0.000504571,0.0002567367,0.00006709051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001910906,0.0002809296,0.2109601,0.0003755032,0.0002749565,0.0000124257,0.0007194421,0.0001415907,0.7739344,0.00004545451,0.000431593,0.01263254],"study_design_scores_gemma":[0.000593778,0.000122121,0.718462,0.0002326591,0.00009031715,0.00000779625,0.000278156,0.003193431,0.2767957,0.00009840804,0.00005145005,0.00007417193],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997934,0.0005907434,0.00007628748,0.0002121282,0.000248738,0.000604827,0.00003719156,0.00001134819,0.0002847322],"genre_scores_gemma":[0.9994244,0.00009348053,0.00009576621,0.00001818171,0.0001314623,0.00003970446,0.00002150285,0.00002342433,0.0001520541],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.507502,"threshold_uncertainty_score":0.3892532,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03862096116607304,"score_gpt":0.4014312457324583,"score_spread":0.3628102845663852,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}