{"id":"W2111793830","doi":"10.1016/j.cell.2010.01.001","title":"Double-Stranded RNA-Dependent Protein Kinase Links Pathogen Sensing with Stress and Metabolic Homeostasis","year":2010,"lang":"en","type":"article","venue":"Cell","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":502,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"Protein kinase R; Biology; Insulin resistance; Nutrient sensing; Kinase; Cell biology; Protein kinase A; EIF-2 kinase; Adipose tissue; Insulin receptor; Endoplasmic reticulum; Unfolded protein response; Signal transduction; Inflammation; Insulin; Endocrinology; Immunology; Mitogen-activated protein kinase kinase; Cyclin-dependent kinase 2","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000648031,0.0001284431,0.0001016302,0.0000285357,0.00006935183,0.00004867486,0.00006230153,0.0001577745,0.000026332],"category_scores_gemma":[0.000006499148,0.0001049342,0.00003691241,0.00004093225,0.00006454925,0.00000396181,0.00003864451,0.0001282455,0.000004810337],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000001732044,"about_ca_system_score_gemma":0.00005443002,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001861401,"about_ca_topic_score_gemma":0.00009579677,"domain_scores_codex":[0.9993439,0.00002221834,0.0001021635,0.0002661906,0.0001055715,0.0001599976],"domain_scores_gemma":[0.999446,0.000002428754,0.00005296445,0.0002694319,0.0000594665,0.0001696592],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002359322,0.00005085465,0.0007540897,0.00002805462,0.00001497428,0.00001831433,0.00002927199,0.00001639464,0.9944286,0.00002986018,0.00002014281,0.004373509],"study_design_scores_gemma":[0.002076341,0.00005688663,0.00278856,0.00000818989,0.00003622405,0.000008425014,0.00005283101,0.00003803492,0.9897261,0.00002396623,0.00500947,0.0001749361],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997344,0.0006235759,0.0003333695,0.00008482939,0.00004849894,0.0002659851,0.00004131386,0.00001441188,0.001244067],"genre_scores_gemma":[0.9976836,0.00004298854,0.001035635,0.00008009732,0.0001206206,0.000007649714,0.00009673464,0.0000191686,0.0009134372],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004989327,"threshold_uncertainty_score":0.4279093,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007055700184915427,"score_gpt":0.2176216247997394,"score_spread":0.210565924614824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}