{"id":"W2111801210","doi":"10.1016/j.stem.2011.04.004","title":"DNA Methylation and SETDB1/H3K9me3 Regulate Predominantly Distinct Sets of Genes, Retroelements, and Chimeric Transcripts in mESCs","year":2011,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":548,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; BC Cancer Agency; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Biology; Methyltransferase; DNA methylation; Gene; Genetics; DNMT3B; Retrotransposon; Epigenetics; Methylation; Heterochromatin protein 1; Histone methylation; Molecular biology; Transposable element; Heterochromatin; Gene expression; Chromatin; Genome","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003113793,0.0003527149,0.0004932567,0.0005244769,0.0002963482,0.0008710253,0.0005226386,0.0003256599,0.001764335],"category_scores_gemma":[0.0002890043,0.0004460708,0.0005337467,0.0002385729,0.0004660253,0.0003751484,0.0006650197,0.001110245,0.0006437736],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005636393,"about_ca_system_score_gemma":0.0002715093,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009059155,"about_ca_topic_score_gemma":0.002157389,"domain_scores_codex":[0.999544,0.00003793948,0.00004451781,0.0001325623,0.0001575196,0.00008346691],"domain_scores_gemma":[0.9996556,0.00007672185,0.00006603249,0.00006786363,0.00004943531,0.00008432734],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005933487,0.000004388352,0.0003349047,0.000009396146,0.000006501988,0.00001415258,0.00001226968,0.00004542794,0.9987836,0.000172991,0.00001136483,0.0005456663],"study_design_scores_gemma":[0.00000985571,0.0000491832,0.01320134,0.000004258191,0.00002870475,0.0001575002,0.00005962524,0.0008716846,0.9843976,0.0001142301,0.00109897,0.000006999758],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897333,0.001448645,0.005311627,0.00007894724,0.00003185194,0.00001705629,0.0007810963,0.0001443922,0.002453049],"genre_scores_gemma":[0.9916033,0.0003231243,0.002595925,0.00007070062,0.000009769343,0.00003006642,0.001067377,0.00009302482,0.004206678],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001764335,"threshold_uncertainty_score":0.00590229,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01582783042181004,"score_gpt":0.215271324043931,"score_spread":0.199443493622121,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}