{"id":"W2111822602","doi":"10.1093/molbev/mst068","title":"An Experimentally Tested Scenario for the Structural Evolution of Eukaryotic Cys2His2 Zinc Fingers from Eubacterial Ros Homologs","year":2013,"lang":"en","type":"article","venue":"Molecular Biology and Evolution","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Biology; Zinc finger; Computational biology; Genetics; Gene duplication; Tandem repeat; Gene; Genome; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001502178,0.0001778824,0.0001725922,0.00003682641,0.0001894458,0.00002156691,0.0002037742,0.0003095645,0.0000445093],"category_scores_gemma":[0.00007787703,0.0001358411,0.00008696927,0.00004080422,0.0002355172,0.00001349778,0.0000644715,0.00005955969,0.000003395618],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003354804,"about_ca_system_score_gemma":0.00005600723,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008488406,"about_ca_topic_score_gemma":0.00003619612,"domain_scores_codex":[0.9989147,0.0001805815,0.0002279685,0.0003737391,0.00005898076,0.0002440666],"domain_scores_gemma":[0.9993523,0.00003449039,0.0001316756,0.0003317628,0.00009050997,0.00005926324],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001833362,0.00002484416,0.004384908,0.000005690884,0.00007221609,3.00725e-7,0.00004987526,0.0000254672,0.9921314,0.001488126,0.00004774084,0.001586156],"study_design_scores_gemma":[0.0008997581,0.001174455,0.05732141,0.00001364919,0.0000710684,0.00001314876,0.0001786532,0.001195693,0.9242166,0.01445442,0.0001977201,0.0002633812],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9080777,0.002675144,0.08818222,0.0001357812,0.0002539021,0.0005876021,0.00005487307,0.00001342586,0.0000193632],"genre_scores_gemma":[0.9950469,0.00002256414,0.004195028,0.00009359048,0.000142758,0.0001429443,0.000315699,0.00001751951,0.00002297133],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08696924,"threshold_uncertainty_score":0.5539441,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006127462361619069,"score_gpt":0.2438633261826423,"score_spread":0.2377358638210233,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}