{"id":"W2111837098","doi":"10.1128/aac.05994-11","title":"Impact of Mutations at Residue I223 of the Neuraminidase Protein on the Resistance Profile, Replication Level, and Virulence of the 2009 Pandemic Influenza Virus","year":2011,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"GlaxoSmithKline (Canada); Université Laval; Centre hospitalier de l'Université Laval","funders":"Canadian Institutes of Health Research; National Institutes of Health; Canada Research Chairs; National Institute for Health and Care Research","keywords":"Neuraminidase; Virulence; Virology; Pandemic; Virus; Biology; Replication (statistics); Influenza A virus; Viral replication; Microbiology; Influenza pandemic; Pandemic influenza; Orthomyxoviridae; Influenza A virus subtype H5N1; Oseltamivir; Genetics; Coronavirus disease 2019 (COVID-19); Gene; Medicine; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002849638,0.000138989,0.000229167,0.0000387709,0.0001939624,0.000006123123,0.0001995487,0.00006154922,0.0000522654],"category_scores_gemma":[0.0002052095,0.00006392543,0.0001003145,0.0002308175,0.0006875296,0.00004616004,0.00009285719,0.0001529462,0.00000116351],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003386739,"about_ca_system_score_gemma":0.00008425368,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000483269,"about_ca_topic_score_gemma":0.00008300384,"domain_scores_codex":[0.9989477,0.0001047557,0.0003331306,0.0002217972,0.0002278896,0.0001647299],"domain_scores_gemma":[0.9987479,0.00007088935,0.0003326519,0.0006365947,0.0001805896,0.00003134869],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001424534,0.0002150408,0.2152286,0.000158559,0.0001703232,5.740121e-7,0.00297452,0.000001357273,0.774657,0.00009608239,0.003764924,0.001308517],"study_design_scores_gemma":[0.0006280004,0.000118921,0.6020008,0.0002184078,0.00001988113,0.000002711357,0.00002986951,0.000005381281,0.3966537,0.00005234312,0.0002281847,0.00004179574],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973604,0.0001115814,0.000002200112,0.0007513249,0.00001259141,0.001237424,0.0001859776,0.000006540897,0.0003319753],"genre_scores_gemma":[0.9975343,0.0003893326,0.00008309943,0.001317562,0.0000133021,0.00002549425,0.000001644743,0.00001481607,0.0006204929],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3867722,"threshold_uncertainty_score":0.2606803,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1261602703529674,"score_gpt":0.3599806958185525,"score_spread":0.2338204254655852,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}