{"id":"W2111837098","doi":"10.1128/aac.05994-11","title":"Impact of Mutations at Residue I223 of the Neuraminidase Protein on the Resistance Profile, Replication Level, and Virulence of the 2009 Pandemic Influenza Virus","year":2011,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"GlaxoSmithKline (Canada); Université Laval; Centre hospitalier de l'Université Laval","funders":"Canadian Institutes of Health Research; National Institutes of Health; Canada Research Chairs; National Institute for Health and Care Research","keywords":"Neuraminidase; Virulence; Virology; Pandemic; Virus; Biology; Replication (statistics); Influenza A virus; Viral replication; Microbiology; Influenza pandemic; Pandemic influenza; Orthomyxoviridae; Influenza A virus subtype H5N1; Oseltamivir; Genetics; Coronavirus disease 2019 (COVID-19); Gene; Medicine; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000192381,0.0004958296,0.000289095,0.0001788278,0.0001638684,0.0003633061,0.0002746033,0.000354509,0.000775911],"category_scores_gemma":[0.000324728,0.0001655415,0.0003493069,0.0001296913,0.0002709437,0.0001203479,0.0001628755,0.000401454,0.0002836878],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007503318,"about_ca_system_score_gemma":0.0004066747,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00836965,"about_ca_topic_score_gemma":0.007500418,"domain_scores_codex":[0.9997709,0.00005175378,0.00002568621,0.00003564673,0.00006390666,0.00005202516],"domain_scores_gemma":[0.9997957,0.00004573915,0.00005419437,0.00001704602,0.00002694907,0.00006037545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000482511,0.0001365354,0.00165101,0.00002762809,0.00004380201,0.000227607,0.00002814241,0.0004598349,0.9950027,0.0000502318,0.00006080101,0.001829283],"study_design_scores_gemma":[0.0001037148,0.003645207,0.04240737,0.00002567734,0.0001940901,0.002037275,0.0001559247,0.006077513,0.9434468,0.00005853369,0.001804806,0.00004300736],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999218,0.000121873,0.0001276511,0.00001524847,0.000006806905,0.00001264674,0.00009350543,0.000009738166,0.0003945019],"genre_scores_gemma":[0.999088,0.00009085171,0.0003138295,0.00002285852,0.000002631425,0.000006116613,0.0001712278,0.00001083982,0.0002935251],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00836965,"threshold_uncertainty_score":0.01664186,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1261602703529674,"score_gpt":0.3599806958185525,"score_spread":0.2338204254655852,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}