{"id":"W2111842648","doi":"10.1124/dmd.106.013243","title":"Expression of the Human UGT1 Locus in Transgenic Mice by 4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic Acid (WY-14643) and Implications on Drug Metabolism through Peroxisome Proliferator-Activated Receptor α Activation","year":2006,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":118,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"National Institute of Environmental Health Sciences; National Institute of General Medical Sciences","keywords":"Peroxisome proliferator-activated receptor; Genetically modified mouse; Peroxisome proliferator; Peroxisome; Transgene; Metabolism; Drug; Locus (genetics); Biology; Chemistry; Pharmacology; Receptor; Endocrinology; Internal medicine; Biochemistry; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003732562,0.0009914128,0.0004624911,0.001280056,0.0004149776,0.0006628904,0.0005556703,0.001315948,0.004094759],"category_scores_gemma":[0.0002505589,0.0007777572,0.0007679855,0.0005079877,0.001069872,0.0004242102,0.0003002895,0.001938626,0.001112211],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006570782,"about_ca_system_score_gemma":0.0005949207,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001943281,"about_ca_topic_score_gemma":0.00370986,"domain_scores_codex":[0.9995646,0.00007483136,0.00004271186,0.0001413623,0.00008545945,0.00009109873],"domain_scores_gemma":[0.9995577,0.00007942997,0.0001946321,0.00004280837,0.00001938692,0.0001060771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003486395,0.00006203551,0.0001450522,0.00002197445,0.00001128154,0.0001540113,0.00002673989,0.00008018672,0.9975082,0.0005419277,0.0001191904,0.0009807257],"study_design_scores_gemma":[0.000172777,0.0002857818,0.001420988,0.0000119761,0.0000625928,0.0008586477,0.00003258088,0.00125411,0.9921681,0.0001661382,0.00355432,0.00001198121],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9670123,0.001613686,0.02115341,0.001217682,0.0002645345,0.0002156068,0.003360914,0.001316176,0.003845635],"genre_scores_gemma":[0.9586862,0.001766327,0.01583347,0.0002554478,0.00007439161,0.0003512327,0.003228333,0.0005861241,0.01921835],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004094759,"threshold_uncertainty_score":0.01369828,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03078434367923374,"score_gpt":0.3366847351071157,"score_spread":0.3059003914278819,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}