{"id":"W2111854172","doi":"10.1073/pnas.032464699","title":"Solution structure and stability of the anti-sigma factor AsiA: Implications for novel functions","year":2002,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; University of Toronto; National Institutes of Health; National Science Foundation","keywords":"Dimer; Promoter; Bacteriophage; Binding site; Sigma factor; Transcription factor; Crystallography; Transcription (linguistics); Biology; Escherichia coli; Chemistry; Biophysics; Stereochemistry; Gene; Biochemistry; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001281365,0.0001611125,0.0001984145,0.0001182338,0.0002577573,0.0004642951,0.0003380531,0.0003440995,0.0008327112],"category_scores_gemma":[0.0002967946,0.0001728779,0.0001142478,0.0001428759,0.0004346373,0.0004890227,0.0002897702,0.0005250916,0.0002548489],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005141164,"about_ca_system_score_gemma":0.0002755743,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006223035,"about_ca_topic_score_gemma":0.0003947146,"domain_scores_codex":[0.9999461,0.000006364228,0.000003065202,0.0000161708,0.00001565221,0.00001260337],"domain_scores_gemma":[0.9998938,0.0000212232,0.00002641653,0.00001098297,0.00002002533,0.00002746347],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003157102,0.00007602059,0.003433746,0.000126543,0.00002311148,0.0001219058,0.0001310881,0.003137053,0.9816747,0.003434121,0.0003839187,0.007142117],"study_design_scores_gemma":[0.0001874847,0.0006175932,0.01704511,0.00004209654,0.00007170442,0.0006102176,0.0004669974,0.04475866,0.9068926,0.01691949,0.01232067,0.00006744621],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903294,0.002609218,0.004486616,0.0004010676,0.00002777875,0.000005494186,0.0001488981,0.00005255142,0.001939089],"genre_scores_gemma":[0.9964389,0.001010864,0.001628871,0.00008863785,0.00002150614,0.000006263007,0.0003776203,0.00001454502,0.000412871],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008327112,"threshold_uncertainty_score":0.003730237,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04502638381329701,"score_gpt":0.277871531733307,"score_spread":0.23284514792001,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}