{"id":"W2111864465","doi":"10.1146/annurev.pathol.2.010506.091847","title":"Cancer Stem Cells: At the Headwaters of Tumor Development","year":2006,"lang":"en","type":"review","venue":"Annual Review of Pathology Mechanisms of Disease","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":161,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"","keywords":"Cancer stem cell; Cancer; Stem cell; Cancer cell; Biology; Cancer research; Prostate cancer; Pathology; Immunology; Medicine; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008623319,0.0005111402,0.003813333,0.0001476424,0.00004676737,0.000001624902,0.0003698447,0.0001283241,0.0003882983],"category_scores_gemma":[0.00004319288,0.0003011073,0.00126426,0.0003112808,0.0002983756,0.00002938358,0.0002555226,0.000216787,0.00002360356],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000164238,"about_ca_system_score_gemma":0.001607298,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003957426,"about_ca_topic_score_gemma":0.00001610656,"domain_scores_codex":[0.9964032,0.0003585944,0.001842885,0.0005135906,0.0005293526,0.0003523659],"domain_scores_gemma":[0.9966803,0.0001070803,0.001741434,0.0008728001,0.0003588371,0.0002395611],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006088816,0.0002222395,0.000001647968,0.4386266,0.0002634775,0.0001578698,0.00004486537,3.13478e-7,0.00007430473,0.0001579696,0.003734649,0.5566552],"study_design_scores_gemma":[0.0003137419,0.0001724896,0.000005248048,0.1465535,0.007288174,0.00004375228,0.00003452046,5.748211e-8,0.003109419,0.00002151563,0.842224,0.000233601],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00006437502,0.9947569,0.00009443419,0.0001374981,0.0003280301,0.002114408,0.002386965,0.00001143921,0.0001059185],"genre_scores_gemma":[0.00002961987,0.9968612,0.0006176697,0.0005989448,0.0000520543,0.0004250647,0.0002227903,0.00006247097,0.001130175],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8384894,"threshold_uncertainty_score":0.9999441,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03275773372600706,"score_gpt":0.3380476968755988,"score_spread":0.3052899631495918,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}