{"id":"W2111941264","doi":"10.1093/nar/gkl1022","title":"Use of modified U1 snRNAs to inhibit HIV-1 replication","year":2006,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Victoria; University of Toronto","funders":"Canadian Institutes of Health Research; Ontario HIV Treatment Network","keywords":"Biology; Replication (statistics); Human immunodeficiency virus (HIV); Virology; Genetics; Viral replication; Computational biology; Cell biology; Virus","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002498575,0.0004021042,0.0003782441,0.0001613758,0.0001945774,0.0003438982,0.000333962,0.0003606504,0.0005994373],"category_scores_gemma":[0.0002132858,0.0002183757,0.000309662,0.0001023229,0.000265,0.0001608949,0.0001892719,0.0005182624,0.0002249661],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002672404,"about_ca_system_score_gemma":0.0001969633,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005022388,"about_ca_topic_score_gemma":0.001023149,"domain_scores_codex":[0.9997801,0.0000594394,0.00002603618,0.0000354237,0.00006078818,0.00003827965],"domain_scores_gemma":[0.9998777,0.00003647422,0.00003586466,0.00002064047,0.00001104386,0.00001815926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005931987,0.00002995721,0.00003690898,0.00002489867,0.000006776631,0.00002402,0.00001304669,0.0001092293,0.998314,0.0001570939,0.0000157914,0.001209025],"study_design_scores_gemma":[0.00001191326,0.0004274812,0.0002596843,0.000003032637,0.00001053893,0.00009246756,0.000005578203,0.0004316806,0.9975013,0.00002704592,0.001225924,0.00000333287],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906101,0.002258112,0.005177109,0.00008477904,0.00005490513,0.00008438074,0.00009234609,0.00009137352,0.001546924],"genre_scores_gemma":[0.9870581,0.001660863,0.009225779,0.00007045082,0.00001686709,0.00005927187,0.0001726006,0.00002296939,0.001713054],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005994373,"threshold_uncertainty_score":0.002005339,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07715047301936942,"score_gpt":0.3462324588049365,"score_spread":0.2690819857855671,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}