{"id":"W2111952057","doi":"10.1074/jbc.m009765200","title":"Real-time Monitoring of the Interactions of Transforming Growth Factor-β (TGF-β) Isoforms with Latency-associated Protein and the Ectodomains of the TGF-β Type II and III Receptors Reveals Different Kinetic Models and Stoichiometries of Binding","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; Biotechnology Research Institute","funders":"","keywords":"Receptor; Transforming growth factor; Gene isoform; Cell biology; Biophysics; Biology; Chemistry; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005572947,0.0006328289,0.0005030471,0.0001911244,0.0001831221,0.0003997638,0.000600361,0.0007877087,0.0006702512],"category_scores_gemma":[0.0005161741,0.000299955,0.0003648086,0.0003479543,0.00033141,0.0004291846,0.0002452322,0.001323191,0.0003438379],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004875486,"about_ca_system_score_gemma":0.0001739188,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004475259,"about_ca_topic_score_gemma":0.0004497515,"domain_scores_codex":[0.9994723,0.00009612233,0.00002588531,0.0001700892,0.000151984,0.00008363064],"domain_scores_gemma":[0.999579,0.0002000654,0.00008443346,0.00002922404,0.00006350511,0.00004375132],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001994522,0.00007227637,0.0002327237,0.00004313877,0.00001270499,0.00001881652,0.00004980817,0.0002016896,0.9971982,0.0001025377,0.00004882327,0.001819849],"study_design_scores_gemma":[0.0000179462,0.0002666163,0.00264313,0.000005606348,0.00001639915,0.00008207696,0.00005440603,0.01886901,0.9774175,0.0000826424,0.0005267306,0.00001797541],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9708466,0.001424678,0.02579508,0.0001449757,0.00005429754,0.00003955493,0.0002929819,0.0002824999,0.001119326],"genre_scores_gemma":[0.9724135,0.001022521,0.02370377,0.0001241932,0.00001377685,0.0001468153,0.0003840986,0.0000370098,0.002154253],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007877087,"threshold_uncertainty_score":0.003537476,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01729783453517055,"score_gpt":0.2401257938902757,"score_spread":0.2228279593551052,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}