{"id":"W2111994713","doi":"10.1681/asn.2010020143","title":"The NLRP3 Inflammasome Promotes Renal Inflammation and Contributes to CKD","year":2010,"lang":"en","type":"article","venue":"Journal of the American Society of Nephrology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":584,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Inflammasome; Inflammation; Kidney disease; Medicine; Kidney; Fibrosis; Acute kidney injury; Caspase 1; Proinflammatory cytokine; Renal function; Immunology; Internal medicine; Pathology; Cancer research","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003262846,0.0002209366,0.0003770636,0.0003598628,0.0002149757,0.0003386707,0.000104928,0.0003353159,0.0008753839],"category_scores_gemma":[0.0002945611,0.0001085833,0.0002545388,0.000202014,0.000409053,0.0002031273,0.0003985813,0.0006170948,0.0001205586],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002539527,"about_ca_system_score_gemma":0.000385926,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004801313,"about_ca_topic_score_gemma":0.0004633252,"domain_scores_codex":[0.999851,0.00004537048,0.00001215305,0.00002176962,0.00004529578,0.00002439396],"domain_scores_gemma":[0.9998815,0.00001362444,0.00004252743,0.0000100125,0.00001743469,0.00003488616],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001790873,0.0002504452,0.02276419,0.0004265584,0.0001163966,0.001712169,0.0001805452,0.0006209323,0.9435533,0.001789162,0.0005552301,0.02624013],"study_design_scores_gemma":[0.0004370234,0.001397517,0.6016915,0.0002219145,0.0004605444,0.02371988,0.0003930884,0.006498511,0.3334431,0.01210174,0.01956555,0.00006967478],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9799427,0.01096421,0.005568086,0.0007838393,0.00003511303,0.00003286302,0.0001581178,0.0001445278,0.002370543],"genre_scores_gemma":[0.9920146,0.004372641,0.002554202,0.000174152,0.00003617062,0.00001672625,0.00005995724,0.00001422476,0.0007572333],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008753839,"threshold_uncertainty_score":0.002928436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003947715916898248,"score_gpt":0.2299030427523924,"score_spread":0.2259553268354942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}