{"id":"W2112028276","doi":"10.1093/hmg/dds433","title":"Selective preservation of MeCP2 in catecholaminergic cells is sufficient to improve the behavioral phenotype of male and female Mecp2-deficient mice","year":2012,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Rehabilitation Institute; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research","keywords":"MECP2; Rett syndrome; Catecholaminergic; Biology; Neuroscience; Phenotype; Neurodevelopmental disorder; Catecholaminergic cell groups; Gene; Genetics; Catecholamine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002685171,0.001012002,0.0006141546,0.0006929094,0.0002148728,0.0003772545,0.0005009894,0.0007165922,0.002170426],"category_scores_gemma":[0.0002382903,0.0002874504,0.0004915403,0.0001670192,0.0004285414,0.0003166575,0.0003721038,0.001130667,0.0006645822],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002475336,"about_ca_system_score_gemma":0.0003090005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007232146,"about_ca_topic_score_gemma":0.00145771,"domain_scores_codex":[0.9996216,0.00003945713,0.00005342241,0.0001248874,0.00009122939,0.0000692983],"domain_scores_gemma":[0.9995326,0.00003337092,0.0001756092,0.00004533416,0.00003334328,0.0001797382],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001511386,0.00005101306,0.0001758862,0.00002549448,0.000009627403,0.00008474423,0.00001702451,0.00003645707,0.9979962,0.0000513815,0.00004136612,0.001359805],"study_design_scores_gemma":[0.00008858567,0.001445261,0.008265996,0.00002310166,0.00008045896,0.00087355,0.00005580138,0.0007050746,0.9852729,0.00006359628,0.003109848,0.00001585043],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886889,0.001563831,0.005327056,0.0003066414,0.0001217875,0.00007825595,0.001620023,0.0004416828,0.001851784],"genre_scores_gemma":[0.9803401,0.001643758,0.005678506,0.0001804941,0.0000503145,0.0001917553,0.001507868,0.0002194807,0.01018764],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002170426,"threshold_uncertainty_score":0.00726074,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01462312267087488,"score_gpt":0.2603235651706027,"score_spread":0.2457004424997279,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}