{"id":"W2112031253","doi":"10.1530/erc-11-0180","title":"Low residual proliferation after short-term letrozole therapy is an early predictive marker of response in high proliferative ER-positive breast cancer","year":2011,"lang":"en","type":"article","venue":"Endocrine Related Cancer","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Fondation Medic; Breast Cancer Research Foundation","keywords":"Letrozole; Breast cancer; Oncology; Medicine; Estrogen receptor; Neoadjuvant therapy; Internal medicine; Cancer; Cancer research; Aromatase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000198959,0.0001252806,0.0002047885,0.000383955,0.00007948095,0.0002176164,0.0001011624,0.0001498037,0.0003741766],"category_scores_gemma":[0.0006769345,0.00009084796,0.0001017434,0.0002051326,0.0001537296,0.0001056246,0.000109326,0.0002082537,0.00009272711],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001569239,"about_ca_system_score_gemma":0.00008561852,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005148067,"about_ca_topic_score_gemma":0.001188978,"domain_scores_codex":[0.9999048,0.00002608317,0.000007589065,0.00001587984,0.00002847343,0.00001712961],"domain_scores_gemma":[0.9996384,0.0001095217,0.0001449038,0.00001834076,0.00002651628,0.00006222815],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002416937,0.00006752364,0.923705,0.00003312654,0.0000440041,0.0001532416,0.0000892645,0.000386313,0.05550666,0.00002045401,0.00007207479,0.01750524],"study_design_scores_gemma":[0.000010768,0.0005023945,0.9921301,0.000002467571,0.00002518714,0.0003572463,0.0000577694,0.0006922254,0.006010375,0.00002796318,0.0001798631,0.000003568986],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994388,0.0002549691,0.0001272261,0.00001320873,0.000001671283,0.000002527775,0.00003646906,0.000006344302,0.0001187601],"genre_scores_gemma":[0.9996656,0.00006021947,0.0001053957,0.000005552894,0.000003084356,0.000002210495,0.00009411178,8.649906e-7,0.00006295912],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005148067,"threshold_uncertainty_score":0.001251698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01061106213852489,"score_gpt":0.2623182601018027,"score_spread":0.2517071979632778,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}