{"id":"W2112031253","doi":"10.1530/erc-11-0180","title":"Low residual proliferation after short-term letrozole therapy is an early predictive marker of response in high proliferative ER-positive breast cancer","year":2011,"lang":"en","type":"article","venue":"Endocrine Related Cancer","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Fondation Medic; Breast Cancer Research Foundation","keywords":"Letrozole; Breast cancer; Oncology; Medicine; Estrogen receptor; Neoadjuvant therapy; Internal medicine; Cancer; Cancer research; Aromatase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001180154,0.000349836,0.0003408715,0.0001219041,0.00006859541,0.00001394266,0.0001448074,0.0001553967,0.000344598],"category_scores_gemma":[0.00001130023,0.0003030154,0.00008573816,0.0002150039,0.000188806,0.000045376,0.00008008513,0.0002131391,0.00000300072],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001844481,"about_ca_system_score_gemma":0.0002640604,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001573416,"about_ca_topic_score_gemma":0.0006436892,"domain_scores_codex":[0.9980879,0.0002465768,0.0003969976,0.0006327235,0.0002328417,0.0004029007],"domain_scores_gemma":[0.9990922,0.00001725563,0.0001408075,0.0003513776,0.0003058209,0.00009255817],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.05795879,0.0006512107,0.8779382,0.00002191033,0.001090404,0.00006513524,0.006232059,0.00007107759,0.05183909,0.00001369566,0.0002282822,0.00389017],"study_design_scores_gemma":[0.001971328,0.0007522622,0.7077324,0.0001094359,0.00005420501,0.00001757311,0.00008542481,0.00001308471,0.2890016,0.00002051142,0.00002196305,0.0002202099],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995064,0.002212325,0.00001464238,0.0004587508,0.0001585365,0.0007654499,0.001160927,0.00002311478,0.0001422759],"genre_scores_gemma":[0.996048,0.001551454,0.0000598571,0.0001809694,0.000189322,0.001463631,0.00009582849,0.00005672821,0.0003541799],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2371625,"threshold_uncertainty_score":0.9999422,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01061106213852489,"score_gpt":0.2623182601018027,"score_spread":0.2517071979632778,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}