{"id":"W2112039383","doi":"10.1093/carcin/bgl059","title":"Activation of the integrin-linked kinase pathway downregulates hepatic connexin32 via nuclear Akt","year":2006,"lang":"en","type":"article","venue":"Carcinogenesis","topic":"Connexins and lens biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Liver Foundation; Armand-Frappier Foundation; Ohio State University","keywords":"Protein kinase B; Integrin-linked kinase; PI3K/AKT/mTOR pathway; GSK3B; Transfection; Cell biology; GSK-3; Chemistry; Phosphorylation; Signal transduction; Cancer research; Biology; Molecular biology; Cell culture; Protein kinase A; Cyclin-dependent kinase 2","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001121108,0.0001599567,0.0001716918,0.00003845403,0.00009404929,0.00000899882,0.0002391534,0.0001865883,0.00006023802],"category_scores_gemma":[0.00005335077,0.0001152443,0.0001771777,0.0001165891,0.0001550881,0.000002970715,0.0001303803,0.00006127232,0.000006816068],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001854847,"about_ca_system_score_gemma":0.00004757266,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003977364,"about_ca_topic_score_gemma":0.0001217214,"domain_scores_codex":[0.9990717,0.0001058229,0.0002507062,0.0002834293,0.00008905411,0.0001993102],"domain_scores_gemma":[0.999188,0.00002383693,0.0001356059,0.0004929833,0.0001252804,0.00003427804],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006463938,0.00005251586,0.01784437,0.00001978957,0.00002770547,8.376328e-7,0.0000282033,0.0000528491,0.9773394,0.0006384957,0.0002576415,0.003673525],"study_design_scores_gemma":[0.0003335766,0.0001225159,0.1452842,0.00001348421,0.00002395542,0.000007406965,0.00005797838,0.0001207562,0.8455997,0.0002081864,0.008077971,0.0001503356],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998171,0.0003989208,0.0001836446,0.0002216027,0.0001357652,0.0001877607,0.00002091157,0.00001339588,0.0006670539],"genre_scores_gemma":[0.9991047,0.00001777309,0.00008902127,0.0002073557,0.0001964687,0.00001256965,0.00007175557,0.00002467345,0.0002756512],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1317398,"threshold_uncertainty_score":0.4699527,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006871624448664811,"score_gpt":0.1940060924547332,"score_spread":0.1871344680060683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}