{"id":"W2112039383","doi":"10.1093/carcin/bgl059","title":"Activation of the integrin-linked kinase pathway downregulates hepatic connexin32 via nuclear Akt","year":2006,"lang":"en","type":"article","venue":"Carcinogenesis","topic":"Connexins and lens biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Liver Foundation; Armand-Frappier Foundation; Ohio State University","keywords":"Protein kinase B; Integrin-linked kinase; PI3K/AKT/mTOR pathway; GSK3B; Transfection; Cell biology; GSK-3; Chemistry; Phosphorylation; Signal transduction; Cancer research; Biology; Molecular biology; Cell culture; Protein kinase A; Cyclin-dependent kinase 2","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001183549,0.0003375304,0.0002656658,0.0001946186,0.0001549459,0.0003361638,0.0000969031,0.0001486954,0.001454305],"category_scores_gemma":[0.000101453,0.0001606381,0.0002364098,0.0001874398,0.0002158541,0.0002119298,0.0001403172,0.0003974193,0.0002675147],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002446831,"about_ca_system_score_gemma":0.0001960145,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007390104,"about_ca_topic_score_gemma":0.0008471564,"domain_scores_codex":[0.9998524,0.0000284215,0.00001476234,0.00002933847,0.00003154765,0.00004337503],"domain_scores_gemma":[0.9999245,0.00001004414,0.00003152664,0.0000104694,0.000008158074,0.00001541639],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003369104,0.0000395154,0.0004449793,0.00006252462,0.000009505156,0.00006325181,0.00002684682,0.00005231876,0.9975072,0.0001971695,0.00005437147,0.001205537],"study_design_scores_gemma":[0.00006076984,0.0005290294,0.01671668,0.00001322764,0.00004847892,0.0002536691,0.0001141517,0.001240119,0.9776833,0.000116402,0.003216878,0.000007375137],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948494,0.002187441,0.001250237,0.000112762,0.00003496002,0.00001095974,0.0001765574,0.00006114912,0.001316572],"genre_scores_gemma":[0.9958567,0.001350657,0.0005609723,0.00003301873,0.000009753296,0.00002110478,0.0002324919,0.00001170881,0.001923524],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001454305,"threshold_uncertainty_score":0.00486511,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006871624448664811,"score_gpt":0.1940060924547332,"score_spread":0.1871344680060683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}